866925-46-4Relevant academic research and scientific papers
Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: Inhibition of interleukin-1β-converting enzyme
Laufersweiler, Michael C.,Wang, Yili,Soper, David L.,Suchanek, Maureen K.,Fancher, Amy N.,Lu, Wei,Wang, Richard L.,Oppong, Kofi A.,Ellis, Christopher D.,Baize, Mark W.,O'Neil, Steven V.,Wos, John A.,Demuth Jr., Thomas P.
, p. 4322 - 4326 (2005)
The application of a tricyclic pyrrolopyrimidinone scaffold for the synthesis of peptidomimetic inhibitors of interleukin-1β-converting enzyme (ICE) is reported. The synthesis of the tricyclic scaffold and conversion of it to a variety of target ICE inhib
