86694-60-2Relevant articles and documents
Near-Infrared Light-Triggered Chlorine Radical (.Cl) Stress for Cancer Therapy
Bu, Wenbo,Gong, Teng,Jiang, Xingwu,Liu, Yanyan,Meng, Xianfu,Song, Ruixue,Wang, Chao-chao,Wang, Han,Wu, Yelin,Zhai, Shaojie,Zhang, Meng
, p. 21032 - 21040 (2020)
Free radicals with reactive chemical properties can fight tumors without causing drug resistance. Reactive oxygen species (ROS) has been widely used for cancer treatment, but regrettably, the common O2 and H2O2 deficiency in tumors sets a severe barrier for sufficient ROS production, leading to unsatisfactory anticancer outcomes. Here, we construct a chlorine radical (.Cl) nano-generator with SiO2-coated upconversion nanoparticles (UCNPs) on the inside and Ag0/AgCl hetero-dots on the outside. Upon near-infrared (NIR) light irradiation, the short-wavelength emission UCNP catalyzes .Cl generation from Ag0/AgCl with no dependence on O2/H2O2. .Cl with strong oxidizing capacity and nucleophilicity can attack biomolecules in cancer cells more effectively than ROS. This .Cl stress treatment will no doubt broaden the family of oxidative stress-induced antitumor strategies by using non-oxygen free radicals, which is significant in the development of new anticancer agents.
CATALYTIC REARRANGEMENT OF THE γ-CHLOROALLYL ETHERS OF PHENOLS
Andreev, N. A.,Bunina-Krivorukova, L. I.,Levashova, V. I.,Aleksandrova, E. K.
, p. 1398 - 1402 (2007/10/02)
The catalytic rearrangement of the γ-chloroallyl ethers of phenol, p- and o-cresol, p- and o-chlorophenol, and 2,4-dichlorophenol takes place by an intermolecular mechanism with the formation of alkenylphenols without inversion of the allylic unit.The transformation of the ethers with a CH3 group (ortho or para) in the benzene ring takes place under milder conditions than that of ethers with a chlorine atom at the same positions.
THERMAL AND CATALYTIC REARRANGEMENTS OF 3-CHLOROALLYL PHENYL ETHER
Levashova, V. I.,Andreev, N. A.,Bunina-Krivorukova, L. I.
, p. 1000 - 1001 (2007/10/02)
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