866947-68-4

Basic information

• Product Name: (S)-(2-{3-[(S)-2-((S)-2-Cyclohexyl-2-isobutoxycarbonylamino-acetylamino)-pent-4-enoylamino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester
• Synonyms: (S)-(2-{3-[(S)-2-((S)-2-Cyclohexyl-2-isobutoxycarbonylamino-acetylamino)-pent-4-enoylamino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester
• CAS NO: 866947-68-4
• Molecular Weight: 729.915
• Mol File: 866947-68-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-(2-{3-[(S)-2-((S)-2-Cyclohexyl-2-isobutoxycarbonylamino-acetylamino)-pent-4-enoylamino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(2-{3-[(S)-2-((S)-2-Cyclohexyl-2-isobutoxycarbonylamino-acetylamino)-pent-4-enoylamino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester(866947-68-4)
• EPA Substance Registry System: (S)-(2-{3-[(S)-2-((S)-2-Cyclohexyl-2-isobutoxycarbonylamino-acetylamino)-pent-4-enoylamino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester(866947-68-4)

Safety Data

• Hazardous Substances Data: 866947-68-4(Hazardous Substances Data)

Upstream product

• 90600-20-7 (2S)-2-[(tert-butoxycarbonyl)amino]pent-4-enoic acid 
• 866947-75-3 {3-[(S)-2-((S)-2-Cyclohexyl-2-isobutoxycarbonylamino-acetylamino)-pent-4-enoylamino]-2-hydroxy-hexanoylamino}-acetic acid allyl ester 
• 866947-72-0 [3-(2-tert-butoxycarbonylamino-pent-4-enoylamino)-2-hydroxy-hexanoylamino]-acetic acid allyl ester 
• 394731-25-0 (S)-cyclohexyl-isobutoxycarbonylamino-acetic acid 
• 53934-78-4 (S)-2-amino-2-phenylacetic acid tert-butyl ester 

Downstream Products

• 866947-79-7 (S)-(2-{3-[(S)-2-((S)-2-Cyclohexyl-2-isobutoxycarbonylamino-acetylamino)-3-[1,3]dithian-2-yl-propionylamino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester 
• 892485-97-1 (S)-(2-{3-[(S)-2-((S)-2-Cyclohexyl-2-isobutoxycarbonylamino-acetylamino)-3-[1,3]dithiolan-2-yl-propionylamino]-2-oxo-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester 
• 866947-85-5 (S)-(2-{3-[(S)-2-((S)-2-Cyclohexyl-2-isobutoxycarbonylamino-acetylamino)-3-cyclopropyl-propionylamino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester 
• 866947-83-3 (S)-(2-{3-[(S)-2-((S)-2-Cyclohexyl-2-isobutoxycarbonylamino-acetylamino)-3-[1,3]dioxan-2-yl-propionylamino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester 
• 866947-77-5 (S)-(2-{3-[(S)-2-((S)-2-Cyclohexyl-2-isobutoxycarbonylamino-acetylamino)-3-[1,3]dithiolan-2-yl-propionylamino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester 
• 866947-81-1 (S)-(2-{3-[(S)-2-((S)-2-Cyclohexyl-2-isobutoxycarbonylamino-acetylamino)-3-[1,3]dioxolan-2-yl-propionylamino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester 

Relevant articles and documents

Hepatitis C virus NS3-4A serine protease inhibitors: Use of a P 2-P1 cyclopropyl alanine combination for improved potency

Modification of the P2 and P1 side chains of earlier P3-capped α-ketoamide inhibitor of HCV NS3 serine protease 1 resulted in the discovery of compound 24 with about 10-fold improvement in potency.