866952-31-0Relevant academic research and scientific papers
Pyridone dipeptides - Synthesis of a novel peptide chromophore
Tremmel, Peter,Geyer, Armin
, p. 3475 - 3481 (2007/10/03)
Sequential elimination of two water molecules transfers the diols 2 and 3 into the pyridone dipeptide 1. Both dehydration steps become part of the peptide synthesis under appropriate reaction conditions. A straightforward strategy for the incorporation of 1 in oligopeptide sequences is presented here. As part of the oligopeptide backbone, 1 has a local rigidifying effect which was studied in the cyclic octapeptides 16 and 25. Both cyclopeptides exhibit conformational averaging although a fixed conformation was identified for the 1-Phe tripeptide fragment of octapeptide 25. The pyridone dipeptide 1 serves also as a fluorescence label and the UV/Vis-spectroscopic properties of tetrapeptide 13 are investigated here. The peptide backbones of the two cyclic octapeptides 16 and 25 arrange a pair of chromophores 1 in close vicinity of each other. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.
