86696-31-3Relevant academic research and scientific papers
Copper-catalyzed nucleophilic trifluoromethylation of allylic halides: A simple approach to allylic trifluoromethylation
Miyake, Yoshihiro,Ota, Shin-Ichi,Nishibayashi, Yoshiaki
, p. 13255 - 13258 (2012)
Trifluoromethylation: The treatment of allylic halides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(I) thiophene-2-carboxylate (CuTC) gives the corresponding allylic trifluoromethylation products in good to high yields and with complete regioselectivity (see scheme). The use of THF as a solvent is crucial for obtaining good yields of product.
