86698-37-5

Upstream product

• 534-22-5 2-methylfuran 
• 1122-91-4 4-bromo-benzaldehyde 
• 1236810-76-6 4-methyl-N-(4-bromophenyl(tosyl)methyl)benzenesulfonamide 
• 36176-90-6 N-(4-bromobenzylidene)-4-methylbenzenesulfonamide 

Downstream Products

• 126810-28-4 2-[(4-Bromo-phenyl)-(5-methyl-thiophen-2-yl)-methyl]-5-methyl-furan 

Relevant academic research and scientific papers

Synthesis method of triarylmethane and derivative thereof under solvent-free condition

The invention discloses a synthesis method of triarylmethane and a derivative thereof under a solvent-free condition and belongs to the field of synthesis of organic compounds. According to the synthesis method disclosed by the invention, sulfamic acid is used as a catalyst and aromatic aldehyde and aromatic hydrocarbon are used as raw materials to synthesize a target object through one-step synthesis. The synthesis method disclosed by the invention has moderate reaction conditions, the catalyst is environmentally friendly and can be recycled and the yield is high; the low yield reaches 43 percent or more and the high yield reaches 98 percent or more; the synthesis method has relatively good universality, small influences on environment and actual popularization and application value.

Green synthesis and anti-inflammatory studies of a series of 1,1-bis(heteroaryl)alkane derivatives

Molecular iodine has been used as an efficient catalyst for a double Friedel-Crafts reaction of various heteroarenes, i.e. 2-methylfuran, 2-ethylfuran, 2-methylthiophene, pyrrole, N-methylpyrrole and indole, using aldehydes as alkylating agents under "open-flask" conditions with toluene or water as the reaction media. In the presence of 10 mol% iodine in toluene at room temperature, both aliphatic and aromatic aldehydes reacted smoothly to give the corresponding bis(heteroaryl)alkanes in good to excellent yields. Interestingly, with water as the solvent, the bis(heteroaryl)alkane adducts were obtained in moderate to good yields. The use of mild reaction conditions, low catalyst loadings, and eco-friendly reagents in a single step synthesis are the advantages of the present procedure. In an effort to discover novel non-steroidal anti-inflammatory agents, the synthesized bis(heteroaryl)alkanes were evaluated for the anti-inflammatory activity in the lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage model. These compounds (50 μM) significantly inhibited NO production and did not exhibit significant cytotoxic effects on macrophage cells. Among them, bis[(5-methyl)2-furyl](4- nitrophenyl) methane exhibited the most potent inhibition of NO with IC 50 value of 42.4 ± 1.9, which is similar to that of the positive control, aminoguanidine (43.3 ± 2.5 μM). Thus, the bis[(5-methyl)2-furyl](4-nitrophenyl) methane could be considered a lead compound for the development of novel anti-inflammatory agents.

Friedel-crafts arylation reactions of N -sulfonyl aldimines or sulfonamidesulfones with electron-rich arenes catalyzed by FeCl 3·6H2O: Synthesis of triarylmethanes and bis-heteroarylarylmethanes

(Figure presented) The FeCl3·6H2O-catalyzed Friedel-Crafts arylation reactions of N-sulfonyl aldimines or sulfonamidesulfones with electron-rich arenes and heteroarenes, which lead to the formation of triarylmethanes and bis-heteroar

POLYFURYL(ARYL)ALKANES AND THEIR DERIVATIVES. 3. SYNTHESIS OF DERIVATIVES OF DIFURYLPHENYL- AND TRIFURYLMETHANE

Previously unknown difurylphenyl- and trifurylmethanes were obtained by the reaction of aromatic aldehydes with furan derivatives in benzene in the presence of perchloric acid.