866994-20-9

Upstream product

• 866994-22-1 (4R)-4-benzyl-3-[(2R)-2-benzylbut-3-enoyl]-1,3-oxazolidin-2-one 
• 762-72-1 allyl-trimethyl-silane 
• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 
• 151215-01-9 (4R)-3-((E)-2-BUTENOYL)-4-(PHENYLMETHYL)-2-OXAZOLIDINONE 

Downstream Products

• 866994-25-4 (4R)-4-benzyl-3-[(2S,3R)-2-benzyl-3-fluoropent-4-enoyl]-1,3-oxazolidin-2-one 
• 866994-28-7 (4R)-4-benzyl-3-[(2S,3S)-2-benzyl-3-fluoropent-4-enoyl]-1,3-oxazolidin-2-one 
• 866994-27-6 (2S,3R)-2-benzyl-3-fluoropent-4-enoic acid 
• 866994-30-1 (2S,3S)-2-benzyl-3-fluoropent-4-enoic acid 

Relevant academic research and scientific papers

Fluorination process

Compounds of formula (II), (IIIa) or (IIIb) (variables are described in the specification) are prepared by fluorination of β,γ-unsaturated alkyl silanes. These compounds are useful as building blocks in the pharmaceutical industry.

Synthesis of novel enantiopure fluorinated building blocks from acyclic chiral allylsilanes

(Chemical Equation Presented) Homochiral β-fluorinated γ,δ-unsaturated carboxylic acids with an allylic fluorinated stereogenic center are available from the corresponding enantiopure allylsilanes. The key step for introduction of the fluorine substituent