867022-57-9

Basic information

• Product Name: L-Valine, N-[(4-bromophenyl)methyl]-N-(1-oxopentyl)-
• CAS NO: 867022-57-9
• Molecular Formula: C17H24BrNO3
• Molecular Weight: 370.286
• Mol File: 867022-57-9.mol

Chemical Properties

• CAS DataBase Reference: L-Valine, N-[(4-bromophenyl)methyl]-N-(1-oxopentyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Valine, N-[(4-bromophenyl)methyl]-N-(1-oxopentyl)-(867022-57-9)
• EPA Substance Registry System: L-Valine, N-[(4-bromophenyl)methyl]-N-(1-oxopentyl)-(867022-57-9)

Safety Data

• Hazardous Substances Data: 867022-57-9(Hazardous Substances Data)

Usage

Uses

Used in Biochemical Research:
L-Valine, N-[(4-bromophenyl)methyl]-N-(1-oxopentyl)is utilized as a research compound for studying the effects of structural modifications on amino acid properties and functions. Its unique chemical composition allows scientists to explore its interactions with biological systems and potential roles in various metabolic pathways.
Used in Pharmaceutical Development:
In the pharmaceutical industry, L-Valine, N-[(4-bromophenyl)methyl]-N-(1-oxopentyl)serves as a key component in the development of new drugs. Its modified structure may provide enhanced bioactivity, selectivity, or stability, making it a valuable asset in the creation of innovative therapeutic agents.
Used in Nutritional Supplements:
As an essential component of proteins, L-Valine, N-[(4-bromophenyl)methyl]-N-(1-oxopentyl)can be incorporated into nutritional supplements to support muscle tissue synthesis and maintenance of nitrogen balance in the body. Its potential enhanced properties may offer additional benefits for athletes or individuals with specific nutritional needs.
Used in Cosmetics and Personal Care Products:
The unique chemical structure of L-Valine, N-[(4-bromophenyl)methyl]-N-(1-oxopentyl)may also find applications in the cosmetics and personal care industry. It could be used as an active ingredient in skincare products, hair care formulations, or other personal care items, leveraging its amino acid properties to improve product efficacy and provide targeted benefits to users.

Upstream product

• 867022-55-7 (S)-2-(4-bromo-benzyl)-amino-3-methyl-butyric acid 
• 638-29-9 n-valeryl chloride 

Downstream Products

• 137862-53-4 valsartan 
• 137862-53-4 N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine 

Relevant articles and documents

A process for the preparation of angiotensin II antagonistic compounds

A process for the preparation of angiotensin II antagonists and novel intermediates useful for the synthesis thereof.

PROCESS FOR THE PREPARATION OF ANGIOTENSIN II ANTAGONISTIC COMPOUNDS

A process for the preparation of angiotensin II antagonists and novel intermediates useful for the synthesis thereof.

PROCESS FOR OBTAINING VALINE DERIVATIVES USEFUL FOR OBTAINING A PHARMACEUTICALLY ACTIVE COMPOUND

The invention provides a method for obtaining the intermediate (II), useful for manufacturing Valsartan and a drug directed to a treatment of arterial hypertension or heart failure. The process comprises a) Imination of the aldehyde group of a compound (VII) by L-Valine (IV) salts with organic or inorganic bases and a polar solvent or water, where X means halogen or an-OSO2R group, where R is CF3, tolyl, methyl or F; to give an imine-type compound (VIII), where B+ is the protonated form of an organic base or an alkaline cation; b) Reduction of the imine group of the compound (VIII) followed by acidification, to give the compound (VI); and c) N-Acylation of the compound (VI) with valeryl chloride to give the compound (II). Steps a) and b) can be performed in a "one pot" reaction.

PROCESS FOR THE PREPARATION OF VALSARTAN AND PRECURSORS THEREOF

This invention relates to a process for preparing intermediates useful in preparing Valsartan and to a process for preparing the latter, together with synthesis intermediates of formula (IV), (V) and (VI), useful for manufacturing a medicament for the treatment of arterial hypertension or heart failure. The process for preparing Valsartan permits it to be prepared on an industrial scale with high yields and without racemisation problems, in addition to using simple and available starting products. The invention also provides a process for preparing the intermediate of formula (VI), from an intermediate of formula (V) that does not require protection of the carboxylic acid prior to N-acylation.