867038-78-6

Basic information

• Product Name: 1-[(benzyloxy)methyl]-5-ethyl-6-(1-amino-2-naphthylthio)uracil
• Synonyms: 1-[(benzyloxy)methyl]-5-ethyl-6-(1-amino-2-naphthylthio)uracil
• CAS NO: 867038-78-6
• Molecular Weight: 433.531
• Mol File: 867038-78-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[(benzyloxy)methyl]-5-ethyl-6-(1-amino-2-naphthylthio)uracil(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(benzyloxy)methyl]-5-ethyl-6-(1-amino-2-naphthylthio)uracil(867038-78-6)
• EPA Substance Registry System: 1-[(benzyloxy)methyl]-5-ethyl-6-(1-amino-2-naphthylthio)uracil(867038-78-6)

Safety Data

• Hazardous Substances Data: 867038-78-6(Hazardous Substances Data)

Upstream product

• 5586-15-2 bis(2-naphthyl)disulfide 
• 728005-41-2 5-ethyl-6-(β-naphthalenethio)uracil 
• 20295-24-3 5-ethyl-6-chloro-2,4-pyrimidinedione 
• 867038-72-0 5-ethyl-6-(1-nitro-2-naphthylthio)uracil 
• 867038-75-3 1-[(benzyloxy)methyl]-5-ethyl-6-(1-nitro-2-naphthylthio)uracil 

Relevant articles and documents

Nonnucleoside HIV-1 reverse-transcriptase inhibitors, part 5.1) synthesis and anti-HIV-1 activity of novel 6-naphthylthio HEPT analogues

As part of a series of studies to discover new HIV reverse-transcriptase inhibitors, various novel 6 α- and 6 β-naphthylthio 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio) thymine (HEPT) derivatives were synthesized, and in vitro anti-HIV-1 activity was evaluated. The results revealed that most of 6α-naphthylthio HEPT derivatives (7a - w) showed good activity [for 7e, IC50 value of 0.048 μM and selectivity index (SI) value of 735; for 7h, IC50 value of 0.057 μM and SI value of 579; for 7k, IC50 value of 0.063 μM and SI value of 565], 6 β-naphthylthio HEPT derivatives (8a - f) showed low activity, but the introduction of α nitro group to the C-1 position of the 6 β-naphthyl ring in the 6 β-naphthylthio series (11a - c) resulted in a dramatic increase in anti-HIV-1 activity.