867068-21-1

Basic information

• Product Name: 9-(3-BROMOPHENYL)-6,9-DIHYDRO[1,3]DIOXOLO[4,5-G]FURO[3,4-B]QUINOLIN-8(5H)-ONE
• Synonyms: 9-(3-BROMOPHENYL)-6,9-DIHYDRO[1,3]DIOXOLO[4,5-G]FURO[3,4-B]QUINOLIN-8(5H)-ONE
• CAS NO: 867068-21-1
• Molecular Formula: C18H12BrNO4
• Molecular Weight: 386.2
• Mol File: 867068-21-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9-(3-BROMOPHENYL)-6,9-DIHYDRO[1,3]DIOXOLO[4,5-G]FURO[3,4-B]QUINOLIN-8(5H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 9-(3-BROMOPHENYL)-6,9-DIHYDRO[1,3]DIOXOLO[4,5-G]FURO[3,4-B]QUINOLIN-8(5H)-ONE(867068-21-1)
• EPA Substance Registry System: 9-(3-BROMOPHENYL)-6,9-DIHYDRO[1,3]DIOXOLO[4,5-G]FURO[3,4-B]QUINOLIN-8(5H)-ONE(867068-21-1)

Safety Data

• Hazardous Substances Data: 867068-21-1(Hazardous Substances Data)

Upstream product

• 541-57-1 4-hydroxy-2(5H)-furanone 
• 3132-99-8 m-bromobenzoic aldehyde 
• 14268-66-7 benzo[1,3]dioxolo-5-ylamine 

Relevant articles and documents

Insecticidal heterolignans-Tubuline polymerization inhibitors with activity against chewing pests

Starting from natural product podophyllotoxin 1 substituted heterolignans were identified with promising insecticidal in vivo activity. The impact of substitution in each segment of the core structure was investigated in a detailed SAR study, and variation of substituents in both aromatic moieties afforded derivatives 5 and 43 with broad insecticidal activity against lepidopteran and coleopteran species. In vitro measurements supported by modeling studies indicate that heterolignans 3-134 act as tubuline polymerization inhibitors interacting with the colchicine-binding site. Insect specific structure-activity effects were observed showing that the insecticidal SAR described herein differs from reported cytotoxicity studies.