86711-45-7

Usage

Uses

Used in Pharmaceutical Synthesis:
(E)-3-(4-(benzyloxy)phenyl)-1-(p-tolyl)prop-2-en-1-one is used as a starting material in the pharmaceutical industry for the synthesis of various organic compounds. Its unique structure and functional groups make it a valuable building block in the development of new drugs and pharmaceutical agents.
Used in Organic Synthesis:
In the field of organic chemistry, (E)-3-(4-(benzyloxy)phenyl)-1-(p-tolyl)prop-2-en-1-one serves as a key intermediate in the synthesis of a wide range of biologically active molecules. Its versatility and reactivity contribute to the creation of complex organic structures with potential applications in various industries.
Used in Research and Development:
(E)-3-(4-(benzyloxy)phenyl)-1-(p-tolyl)prop-2-en-1-one is also utilized in research and development for the exploration of its potential therapeutic properties. Studies have shown promising results in various pharmacological applications, making it a valuable compound for further investigation and development in the medical field.
Used in Drug Design and Development:
(E)-3-(4-(benzyloxy)phenyl)-1-(p-tolyl)prop-2-en-1-one is used as a building block in drug design and development, particularly for the creation of novel biologically active molecules with potential therapeutic applications. Its unique structure and functional groups allow for the development of innovative drugs with improved efficacy and selectivity.

Upstream product

• 4397-53-9 p-benzyloxybenzaldehyde 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 1187024-10-7 5-(4-(benzyloxy)phenyl)-3-(4-methylphenyl)-1-thiocarbamoyl-4,5-dihydro-1H-pyrazole 
• 1198426-66-2 5-(4-(benzyloxy)phenyl)-3-(4-methylphenyl)-4,5-dihydroisoxazole 
• 1198426-63-9 5-(4-(benzyloxy)phenyl)-1-phenyl-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole 
• 1374585-13-3 4-(4-benzyloxyphenyl)-6-p-tolyl-2,2'-bipyridine 

Relevant academic research and scientific papers

Chalcones and bis-chalcones: As potential α-amylase inhibitors; synthesis, in vitro screening, and molecular modelling studies

Despite of a diverse range of biological activities associated with chalcones and bis-chalcones, they are still neglected by the medicinal chemist for their possible α-amylase inhibitory activity. So, the current study is based on the evaluation of this c

Chalcones and bis-chalcones analogs as DPPH and ABTS radical scavengers

Background: A number of synthetic scaffolds, along with natural products, have been identified as potent antioxidants. The present study deals with the evaluation of varyingly substituted, medicinally distinct class of compounds “chalcones and bis-chalcon

Antiproliferative effects of chalcones on T cell acute lymphoblastic leukemia-derived cells: Role of PKCβ

In this study, a series of 20 chalcone derivatives was synthesized, and their antiproliferative activity was tested against the human T cell acute lymphoblastic leukemia-derived cell line, CCRF-CEM. On the basis of the structural features of the most active compounds, a new library of chalcone derivatives, according to the structure–activity relationship design, was synthesized, and their antiproliferative activity was tested against the same cancer cell line. Furthermore, four of these derivatives (compounds 3, 4, 8, 28), based on lower IC50 values (between 6.1 and 8.9 μM), were selected for further investigation regarding the modulation of the protein expression of RACK1 (receptor for activated C kinase), protein kinase C (PKC)α and PKCβ, and their action on the cell cycle level. The cell cycle analysis indicated a block in the G0/G1 phase for all four compounds, with a statistically significant decrease in the percentage of cells in the S phase, with no indication of apoptosis (sub-G0/G1 phase). Compounds 4 and 8 showed a statistically significant reduction in the expression of PKCα and an increase in PKCβ, which together with the demonstration of an antiproliferative role of PKCβ, as assessed by treating cells with a selective PKCβ activator, indicated that the observed antiproliferative effect is likely to be mediated through PKCβ induction.

Synthesis and biological evaluation of aromatic enones related to curcumin

Curcumin, a natural product isolated from the spice turmeric, has been shown to exhibit a wide range of pharmacological activities including certain anti-cancer properties. It has been specifically shown to be an effective inhibitor of angiogenesis both in vitro and in vivo. Using curcumin as a lead compound for anti-angiogenic analog design, a series of structurally related compounds utilizing a substituted chalcone backbone have been synthesized and tested via an established SVR cell proliferation assay. The results have yielded a wide range of compounds that equal or exceed curcumin's ability to inhibit endothelial cell growth in vitro. Due to both their commercial availability and their fairly straightforward synthetic preparation, these low molecular weight compounds are attractive leads for developing future angiogenic inhibitors.