867131-59-7

Basic information

• Product Name: 4-Chloro-2-methyl-6-(methylthio)pyrimidine
• Synonyms: 4-Chloro-2-methyl-6-(methylthio)pyrimidine;4-Chloro-2-Methyl-6-(Meth...;4-chloro-2-methyl-6-(methylsulfanyl)pyrimidine;4-Chloro-6-methanesulfonyl-2-methyl-pyrimidine
• CAS NO: 867131-59-7
• Molecular Formula: C6H7ClN2S
• Molecular Weight: 174.65118
• Mol File: 867131-59-7.mol

Chemical Properties

• Boiling Point: 254℃
• Flash Point: 107℃
• Appearance: /
• Density: 1.30
• CAS DataBase Reference: 4-Chloro-2-methyl-6-(methylthio)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-methyl-6-(methylthio)pyrimidine(867131-59-7)
• EPA Substance Registry System: 4-Chloro-2-methyl-6-(methylthio)pyrimidine(867131-59-7)

Safety Data

• Hazardous Substances Data: 867131-59-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Chloro-2-methyl-6-(methylthio)pyrimidine is used as a building block in the synthesis of pharmaceuticals. Its unique structure and reactivity allow for the creation of new compounds with potential biological activities, contributing to the development of novel therapeutic agents.
Used in Agrochemical Production:
4-Chloro-2-methyl-6-(methylthio)pyrimidine is also utilized in the production of agrochemicals, such as herbicides, fungicides, and insecticides. Its role as an intermediate in these processes helps in the development of effective and targeted pest control solutions.
Used in Organic Synthesis:
4-Chloro-2-methyl-6-(methylthio)pyrimidine serves as a valuable precursor in organic synthesis. Its properties enable the creation of a wide range of heterocyclic compounds, expanding the scope of chemical research and innovation.
It is crucial to handle 4-Chloro-2-methyl-6-(methylthio)pyrimidine with care due to its potential health and environmental hazards if not properly managed.

Upstream product

• 17551-53-0 2-methyl-6-methylsulfanyl-3H-pyrimidin-4-one 
• 1780-26-3 2,4-dichloro-2-methylpyrimidine 
• 5188-07-8 sodium thiomethoxide 
• 17551-52-9 6-chloro-2-methyl-3,4-dihydropyrimidin-4-one 

Relevant articles and documents

INDAZOLYL-SPIRO[2.2]PENTANE-CARBONITRILE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

The present invention is directed to substituted certain reversed indazolyl-spiro[2.2]pentane-carbonitrile derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Structure-based design of a novel series of potent, selective inhibitors of the class i phosphatidylinositol 3-kinases

A highly selective series of inhibitors of the class I phosphatidylinositol 3-kinases (PI3Ks) has been designed and synthesized. Starting from the dual PI3K/mTOR inhibitor 5, a structure-based approach was used to improve potency and selectivity, resulting in the identification of 54 as a potent inhibitor of the class I PI3Ks with excellent selectivity over mTOR, related phosphatidylinositol kinases, and a broad panel of protein kinases. Compound 54 demonstrated a robust PD-PK relationship inhibiting the PI3K/Akt pathway in vivo in a mouse model, and it potently inhibited tumor growth in a U-87 MG xenograft model with an activated PI3K/Akt pathway.