867151-29-9

Upstream product

• 54197-66-9 3,4-dihydro-6-hydroxy-2(1H)-quinolinone 
• 100-44-7 benzyl chloride 
• 75893-83-3 6-(benzyloxy)-3,4-dihydroquinolin-2(1H)-one 
• 121-44-8 triethylamine 
• 123-30-8 4-amino-phenol 

Downstream Products

• 1039717-05-9 C₁₆H₁₇N₃O 
• 1352080-25-1 7-(2-fluorobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 
• 1352080-26-2 7-(3-fluorobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 
• 1352080-27-3 7-(4-fluorobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 
• 1352080-28-4 7-(2-chlorobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 
• 1352080-29-5 7-(3-chlorobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 
• 1352080-30-8 7-(4-chlorobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 
• 1352080-31-9 7-(2-bromobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 
• 1352080-32-0 7-(3-bromobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 
• 1352080-33-1 7-(4-methylbenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 
• 1352080-34-2 7-(4-methoxybenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 
• 1352080-35-3 7-(4-aminobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 
• 1352080-17-1 7-benzyloxy-4,5-dihydrotetrazolo[1,5-a]quinoline 
• 1426933-49-4 C₂₀H₂₄N₂O₃ 

Relevant academic research and scientific papers

Synthesis and anticonvulsant activity of 1-substituted-7-benzyloxy-4,5- dihydro-[1,2,4]triazolo[4,3-a]quinoline

Starting from 6-hydroxy-3,4-dihydro-1H-quinoline-2-one, a series of 1-substituted-7-benzyloxy-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines was synthesized and their structures were characterized using IR, 1H-NMR, MS, and elemental analysis techniques. Anticonvulsant activity was evaluated in the maximal electroshock (MES) test, subcutaneous pentylenetetrazol (scMet) test, and rotarod neurotoxicity test. The most active compound was 7-benzyloxy-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline 4a. Its ED50 in the MES and scMet tests was 17.3 and 24mg·kg-1, respectively. The safest compound was 4g, 1-phenyl-7-benzyloxy-4,5-dihydro-[1,2, 4]triazolo[4,3-a]quinoline, with TD50 and protective index (PI) (PI=TD50/ED50) values of greater than 300mg·kg -1 and 13, respectively. The PI value of compound 4g was better than that of most marketed drugs. Structure-activity relationships are also described in this paper.

Synthesis and evaluation of antibacterial activity of 7-alkyloxy-4,5- dihydro-imidazo[1,2-a]quinoline derivatives

In this study, a series of 7-alkyloxy-4,5-dihydro-imidazo[1,2-a]quinoline derivatives was synthesized and tested for their antibacterial activity against various bacterial strains. Most of the compounds exhibited potential antibacterial activity against g

Synthesis and study of the antidepressant activity of novel 4,5-dihydro-7-Alkoxy(phenoxy)-tetrazolo[1,5-A]quinoline derivatives

In this study, a novel series of 4,5-dihydro-7-Alkoxy(phenoxy)-tetrazolo[1, 5-A]quinoline derivatives was synthesized as potential antidepressant agents. Their antidepressant activities were evaluated by the forced swimming test and tail suspension test m

Synthesis and anticonvulsant activity of 1-formamide-triazolo[4,3-a] quinoline derivatives

Using 6-hydroxy-3,4-dihydro-2(1H)-quinolone as the starting material, a series of 1-formamide-triazolo[4, 3-a]quinoline derivatives (6a-6n) was synthesized, the anticonvulsant effect and neurotoxicity of the compounds was calculated with maximal electrosh

Design, synthesis of 8-alkoxy-5,6-dihydro-[1,2,4]triazino[4,3-a]quinolin-1-ones with anticonvulsant activity

A new series of 8-alkoxy-5,6-dihydro-[1,2,4]triazino[4,3-a]quinolin-1-one derivatives were synthesized. Their anticonvulsant activities were evaluated by the maximal electroshock (MES) test, and their neurotoxicities were evaluated by the rotarod neurotox

Synthesis and anti-inflammatory activity evaluation of novel 7-alkoxy-1-amino-4,5-dihydro[1,2,4]triazole[4,3-a]quinolines

In this study, a novel series of 7-alkoxy-1-amino-4,5-dihydro[1,2,4] triazole[4,3-a]quinolines were synthesized by using 6-hydroxy-3,4-dihydro-2(1H)- quinolone as the starting material. These compounds were evaluated for anti-inflammatory activity through

Anticonvulsant and toxicity evaluation of some 7-alkoxy-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline-1(2H)-ones

To further investigate anticonvulsant activity of quinoline derivatives, a series of 7-alkoxy-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline-1(2H)-one derivatives was synthesized starting from 7-hydroxyl-3,4-dihydro-2(1H)-quinoline. In initial (phase I) scre