867151-48-2

Basic information

• Product Name: 5-[(2,4-difluorobenzyl)amino]dihydropyrimidine-2,4(1H,3H)-dione
• CAS NO: 867151-48-2
• Molecular Weight: 253.208
• Mol File: 867151-48-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-[(2,4-difluorobenzyl)amino]dihydropyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(2,4-difluorobenzyl)amino]dihydropyrimidine-2,4(1H,3H)-dione(867151-48-2)
• EPA Substance Registry System: 5-[(2,4-difluorobenzyl)amino]dihydropyrimidine-2,4(1H,3H)-dione(867151-48-2)

Safety Data

• Hazardous Substances Data: 867151-48-2(Hazardous Substances Data)

Upstream product

• 51-20-7 5-bromouracil 
• 72235-52-0 2,4-Difluoro-benzylamine 

Downstream Products

• 1301726-15-7 1-(2'-acetoxyethoxymethyl)-5-(2'',4''-difluorobenzylamino)uracil 
• 867151-52-8 2,4-dichloro-N-(2,4-difluorobenzyl)pyrimidin-5-amine 

Relevant articles and documents

Novel 5-(N -alkylaminouracil) acyclic nucleosides

Protocols for the two-step syntheses of new 5-(N-hydroxyalkyl- and 5-N-benzylamino)uracil acyclic nucleosides bearing various functional groups (alkoxy/hydroxy and cyano/ester) are presented. Two groups of the title compounds were synthesised via aminolysis of 5-bromouracil and, subsequently, either coupling with an alkylating agent (2-chloromethoxyethyl acetate), or Michael-type addition to acrylonitrile/methyl acrylate. The reverse sequences for both syntheses were also studied. The target molecules were designed as non-nucleoside reverse transcriptase inhibitors (NNRTI) and are analogues of 1-(hydroxyethoxymethyl)-6-thiophenylthymine (HEPT) and 3-benzyl-1- cyanomethyluracils. The obtained compounds will be used in screening tests for anti-HIV-1 activity. Georg Thieme Verlag Stuttgart New York.