867177-63-7Relevant academic research and scientific papers
Synthesis of some new thiosemicarbazide and 1,2,4-triazoles heterocycles bearing thiophene nucleus as a potent antitubercular and antimicrobial agents
Vasoya,Chovatia,Paghdar,Joshi
, p. 709 - 710 (2008/09/20)
The starting compound 2-hydrazino carbonyl-3-chloro-5-phenoxy-benzo(b) thiophene on reaction with different substituted phenyl isothiocyanates to give N-substituted arylthiosemicarbazide derivatives (1a-h). 1,2,4-Triazole derivatives (2a-h) have been prepared by the cyclization of arylthiosemicarbazides (1a-h) with sodium hydroxide. All the compounds were screened for their antitubercular activity against Mycobacterium tuberculosis (H37Rv) and some other microbes.
