86725-96-4Relevant academic research and scientific papers
C-H functionalization/C-N bond formation: Copper-catalyzed synthesis of benzimidazoles from amidines
Brasche, Gordon,Buchwald, Stephen L.
, p. 1932 - 1934 (2008/12/22)
(Chemical Equation Presented) Copper closes the ring: Benzimidazoles are synthesized from amidines through a copper-catalyzed C-H functionalization/ C-N bond-forming process. The method tolerates a broad range of functional groups and provides the benzimidazoles in up to 89% yield. Best results are obtained by using 15 mol% Cu(OAc)2, 2-5 equivalents of HOAc as additive, and oxygen as the stoichiometric reoxidant (see scheme).
2,3-Diaryl-5-anilino[1,2,4]thiadiazoles as melanocortin MC4 receptor agonists and their effects on feeding behavior in rats
Pan, Kevin,Scott, Malcolm K.,Lee, Daniel H. S.,Fitzpatrick, Louis J.,Crooke, Jeffery J.,Rivero, Ralph A.,Rosenthal, Daniel I.,Vaidya, Anil H.,Zhao, Boyu,Reitz, Allen B.
, p. 185 - 192 (2007/10/03)
The melanocortin-4 receptor (MC4) modulates physiological functions such as feeding behavior, nerve regeneration, and drug addiction. Using a high throughput screen based on 125I-NDP-MSH binding to the human MC4 receptor, we discovered 2,3-diar
