867287-75-0

Upstream product

• 1824-96-0 methyl ribofuranoside 
• 867287-72-7 methyl 2-C-α-(benzenesulfonyl-1',1'-difluoro)methyl-3,5-di-O-tert-butylsilanediyl-β-D-arabinofuranoside 
• 867287-73-8 methyl 2-C-α-difluoromethyl-3,5-di-O-tert-butylsilanediyl-β-D-arabinofuranoside 
• 867287-68-1 methyl 3,5-di-O-tert-butylsilanediyl-β-D-ribofuranoside 
• 867287-71-6 methyl 3,5-di-O-tert-butylsilanediyl-2-oxo-β-D-erythro-ribofuranoside 
• 867287-74-9 methyl 2-C-α-difluoromethyl-2-O-benzoyl-3,5-di-O-tert-butylsilanediyl-β-D-arabinofuranoside 

Downstream Products

• 867287-76-1 methyl 2-C-α-difluoromethyl-2,3,5-tri-O-benzoyl-β-D-arabinofuranoside 

Relevant academic research and scientific papers

Synthesis of 2′-C-difluoromethylribonucleosides and their enzymatic incorporation into oligonucleotides

Nucleosides bearing a branched ribose have significant promise as therapeutic agents and biotechnological and biochemical tools. Here we describe synthetic entry into a new subclass of these analogues, 2′-C-β- difluoromethylribonucleosides. We constructed