867287-84-1

Upstream product

• 75532-25-1 2,2,4,4-tetrahydrothiophene-3,4-dicarboxylic acid anhydride 
• 92-67-1 4-phenylalanine 
• 2689-68-1 methyl 4-oxotetrahydrothiophene-3-carboxylate 
• 155251-31-3 3-hydroxy-tetrahydro-thiophene-3,4-dicarboxylic acid 
• 155251-30-2 3-cyano-3-hydroxy-tetrahydrothiophene-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors

Novel DHODH inhibitors were developed based on a previously described series by introduction of heteroatoms into the cyclopentene ring and hydroxyl groups attached to it. Also, the hydrophobic biphenyl side chain was replaced with benzyloxy phenyl groups. Activities on human, rat, and mouse enzymes indicate a species specificity of these inhibitors.

Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents

The present invention relates to novel compounds that can be used as antiinflammatory, immunomodulatory and antiproliferatory agents. In particular the invention refers to new compounds which inhibit dihydroorotate dehydrogenase (DHODH), a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of diseases, in particular their use in diseases where there is an advantage in inhibiting dihydroorotate dehydrogenase (DHODH).