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TG 100572 (Hydrochloride) is a chemical compound that functions as a selective and potent inhibitor of the cyclin-dependent kinase 9 (CDK9) enzyme. It is recognized for its potential therapeutic applications in the treatment of various cancers, including both hematological malignancies and solid tumors. TG 100572 (Hydrochloride)'s ability to inhibit CDK9 results in the disruption of transcriptional elongation in cancer cells, thereby inhibiting their growth and proliferation. TG 100572 (Hydrochloride) has demonstrated promising anti-cancer activity in preclinical studies and is under investigation in clinical trials for its potential as a cancer treatment.

867331-64-4

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867331-64-4 Usage

Uses

Used in Pharmaceutical Industry:
TG 100572 (Hydrochloride) is used as an anti-cancer agent for its ability to inhibit the CDK9 enzyme, which is crucial in the regulation of cell cycle progression. By targeting this enzyme, the compound disrupts the transcriptional elongation process in cancer cells, leading to the suppression of tumor cell growth and proliferation.
Used in Cancer Research:
In the field of cancer research, TG 100572 (Hydrochloride) serves as a valuable tool for studying the role of CDK9 in cancer development and progression. Its use in preclinical studies has provided insights into the mechanisms by which it can be leveraged to combat cancer, paving the way for further development and optimization of CDK9-targeted therapies.
Used in Clinical Trials:
TG 100572 (Hydrochloride) is utilized in clinical trials to evaluate its safety, efficacy, and potential as a treatment for various types of cancer. These trials are essential for determining the optimal dosing, administration, and patient populations that may benefit from TG 100572 (Hydrochloride), ultimately contributing to the advancement of cancer therapeutics.

Check Digit Verification of cas no

The CAS Registry Mumber 867331-64-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,7,3,3 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 867331-64:
(8*8)+(7*6)+(6*7)+(5*3)+(4*3)+(3*1)+(2*6)+(1*4)=194
194 % 10 = 4
So 867331-64-4 is a valid CAS Registry Number.

867331-64-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-chloro-3-[5-methyl-3-[4-(2-pyrrolidin-1-ylethoxy)anilino]-1,2,4-benzotriazin-7-yl]phenol,hydrochloride

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:867331-64-4 SDS

867331-64-4Upstream product

867331-64-4Downstream Products

867331-64-4Relevant academic research and scientific papers

Benzotriazine inhibitors of kinases

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Page/Page column 134, (2008/06/13)

The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.

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