867331-82-6

Basic information

• Product Name: TG100801
• Synonyms: TG100801;Phenol, 4-chloro-3-[5-Methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-1,2,4-benzotriazin-7-yl]-, 1-benzoate;4-Chloro-3-[5-methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-1,2,4-benzotriazin-7-yl]phenol 1-benzoate;4-Chloro-3-(5-methyl-3-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-amino)benzo[e][1,2,4]triazin-7-yl)p;4-Chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenyl benzoate;4-Chloro-3-(5-methyl-3-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-amino)benzo[e][1,2,4]triazin-7-y
• CAS NO: 867331-82-6
• Molecular Formula: C33H30ClN5O3
• Molecular Weight: 580.076
• Mol File: 867331-82-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 747.9±70.0 °C(Predicted)
• Appearance: /
• Density: 1.310
• Solubility: Soluble in DMSO
• PKA: 9.59±0.20(Predicted)
• CAS DataBase Reference: TG100801(CAS DataBase Reference)
• NIST Chemistry Reference: TG100801(867331-82-6)
• EPA Substance Registry System: TG100801(867331-82-6)

Safety Data

• Hazardous Substances Data: 867331-82-6(Hazardous Substances Data)

Usage

Biological Activity

tg100801 is a multi-kinases inhibitor. it is a pro-drug version of tg100572. [1]tg100572 inhibits several growth factor receptors in addition to src family kinases. tg100801 significantly inhibited laser-induced cnv in mice, and suppressed fluorescein leakage from the vasculature and retinal thickening measured by optical coherence tomography in a rat model or retinal vein occlusion. tg100801 may play as a new topically applied treatment approach for ocular neovascularization and retinal edema. the highest concentration of tg100801 was found at the front of the rat eye (conjunctiva and cornea). [1]

references

1. doukas j, mahesh s, umeda n et al. topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema. j cell physiol. 2008 jul;216(1):29-37.