867349-72-2Relevant academic research and scientific papers
Nitroimidazoles, part 1. An unexpected reactivity during the cyclization of 3-(4-amino-1-benzyl-2-ethyl-1H-imidazol-5-ylsulphanyl)-propionic acid methyl ester
Al-Soud, Yaseen A.,Al-Masoudi, Najim A.
, p. 2259 - 2264 (2005)
Nucleophilic substitution of the 5-bromo group in 1 by methyl 3-mercaptopropionate gave the 5-alkyl-mercapto derivative 2. Reduction of 2 with H2/Pd led to the amine 3, meanwhile reduction with Fe/HOAc afforded the 5-acetamido derivative 4 and
