86764-30-9Relevant academic research and scientific papers
A Facile and High-yielding Preparation of 1-Aryl-3,3-dialkylureas
Xian, Ming,Lu, Jianming,Zhu, Xiaoqing,Mu, Linjing,Cheng, Jin-Pei
, p. 442 - 443 (2007/10/03)
A convenient procedure for the preparation of 1-aryl-3,3-dialkylureas using bis(trichoromethyl) carbonate ('triphosgene') is described.
Transnitrosation by N-aryl-N-nitrosoureas; NO-carrying O-nitrosoisourea
Tanno,Sueyoshi,Miyata
, p. 1760 - 1767 (2007/10/02)
Transfer of nitroso groups, so-called transnitrosation, from aromatic N-nitroso compounds such as N-nitrosoureas, N-nitrosamides and N-nitrosamines, to aromatic amines or ureas was observed under non-acidic conditions at room temperature. Sterically hindered 3,3-dibenzyl-1-(4-tolyl)-1-nitrosourea (1a) rapidly nitrosates indoline, N-alkylanilines or 3-methyl-1-(4-tolyl)urea to give their N-nitroso derivatives. In the case of N,N-dimethylanilines, nitrosative demethylation occurs to give N-methyl-N-nitrosanilines. The transnitrosation is accelerated by electron-releasing groups on the nitroso acceptors, N-alkylanilines. The transnitrosation mechanism is considered to be as follows: N-nitrosourea (1) thermally decomposes to nitric oxide and ureidyl radical followed by formation of an O-nitrosoisourea intermediate (10), which acts as an NO-carrying agent and nitrosates anilines or ureas.
Potential Antiatherosclerotic Agents. 6. Hypocholesterolemic Trisubstituted Urea Analogues
DeVries, Vern G.,Bloom, Jonathan D.,Dutia, Minu D.,Katocs, Andrew S.,Largis, Elwood E.
, p. 2318 - 2325 (2007/10/02)
The discovery that a series of N,N-dialkyl-N'-arylureas were inhibitors of the ACAT enzyme has led to a structure-activity study involving the systematic modification of three sites of the urea backbone.This study culminated in the selection of N'-(2,4-dimethylphenyl)-N-benzyl-N-n-butylurea (115) for more extensive biological evaluation.ACAT inhibitors are seen as potentially beneficial agents against hypercholesterolemia and atherosclerosis.
Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas
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, (2008/06/13)
Methods of treating atherosclerosis with di(aralkyl) ureas and di(aralkyl)thioureas, compositions thereof and processes for their preparation.
