86781-45-5Relevant academic research and scientific papers
Potential Antiatherosclerotic Agents. 6. Hypocholesterolemic Trisubstituted Urea Analogues
DeVries, Vern G.,Bloom, Jonathan D.,Dutia, Minu D.,Katocs, Andrew S.,Largis, Elwood E.
, p. 2318 - 2325 (2007/10/02)
The discovery that a series of N,N-dialkyl-N'-arylureas were inhibitors of the ACAT enzyme has led to a structure-activity study involving the systematic modification of three sites of the urea backbone.This study culminated in the selection of N'-(2,4-dimethylphenyl)-N-benzyl-N-n-butylurea (115) for more extensive biological evaluation.ACAT inhibitors are seen as potentially beneficial agents against hypercholesterolemia and atherosclerosis.
Methods of treating atherosclerosis with dialkylureas and dialkylthioureas
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, (2008/06/13)
Method of treating atherosclerosis with dialkylureas and dialkylthioureas, compositions thereof and processes for their preparation.
