86790-89-8Relevant academic research and scientific papers
Valine amide carbamate derivative containing propargyloxy group and application thereof
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Paragraph 0054; 0055; 0056; 0061; 0062, (2017/08/25)
The invention relates to a valine amide carbamate derivative containing a propargyloxy group and a pharmaceutically acceptable salt thereof, belonging to the field of botanical bactericides. The valine amide carbamate derivative has a general formula (I) as shown in the specification, and the substituent R in the general formula (I) is as defined in the specification. The invention also relates to a preparation method for the compound as shown in the general formula (I), an intermediate specially prepared for development of the compound and application of the compound to prevention and treatment of plant diseases.
Formal aromatic C-H insertion for stereoselective isoquinolinone synthesis and studies on mechanistic insights into the C-C bond formation
Park, Chan Pil,Nagle, Advait,Cheol, Hwan Yoon,Chen, Chiliu,Kyung, Woon Jung
supporting information; scheme or table, p. 6231 - 6236 (2009/12/08)
(Chemical Equation Presented) Formal aromatic C-H insertion of rhodium(II) carbenoid was intensively investigated to develop a new methodology and probe its mechanism. Contrasting with the previously proposed direct C-H insertion, the mechanism was revealed to be electrophilic aromatic substitution, which was supported by substituent effects on the aromatic ring and a secondary deuterium kinetic isotope effect. Various isoquinolinones were synthesized intramolecularly via six-membered ring formation with high regioand diastereoselectivity, while averting the common Buchner-type reaction. Intermolecularly, dirhodium catalyzed formal aromatic C-H insertion on electron-rich aromatics was also achieved.
Kinetics and Mechanism of the Alkaline Release of Phenyl(mercapto)tetrazoles from α-Oximes
Boggs, Roger A.,Hasan, Fariza B.,Mahoney, J. Barry,Mehta, Avi C.,Palumbo, Catherine M. K.,et al.
, p. 1271 - 1277 (2007/10/02)
Compounds such as α-phenyl(mercapto)tetrazole (PMT) oxime (9) undergo rapid elimination of the PMT anion in base via a nitrosoene intermediate.Solution kinetics and HPLC analysis of reaction products are consistent with the mechanism shown in Scheme 2.For open chain oximes such as 4, substitution α to the oxime increases the rate of release of PMT and is attributed to the relief of strain when a crowded reactant is converted to a less-crowded product.For cyclic oximes, the six-membered ring compounds are more reactive than the corresponding five-membered compounds.A linear isokinetic relationship between the entropy and enthalpy of activation was found with β = 346 +/- 51 K.Entropies of activation were found to range from -7 to +24 c.u. (1 c.u. = 4.184 J mol-1 K-1) and support the proposed mechanism.
