86796-01-2

Usage

Uses

Used in Pharmaceutical Industry:
(6Z)-2,2-dimethyl-N-phenyl-6-(phenylimino)-3,6-dihydro-2H-thiopyran-4-amine is used as a potential pharmaceutical compound for its possible biological activities. The presence of a thiopyran ring and amine group, along with phenyl and methyl substituents, suggests that it may interact with biological targets, making it a candidate for drug development. However, further research is needed to explore its full potential and efficacy.
Used in Chemical Research:
In the field of chemical research, (6Z)-2,2-dimethyl-N-phenyl-6-(phenylimino)-3,6-dihydro-2H-thiopyran-4-amine can be used as a subject for studying the properties and reactivity of thiopyranamines. Its unique structural features may provide insights into the synthesis and modification of related compounds, contributing to the advancement of organic chemistry.

Upstream product

• 84260-96-8 (2,2-Dimethyl-6-methylsulfanyl-2,3-dihydro-thiopyran-4-ylidene)-dimethyl-ammonium; iodide 
• 84260-98-0 4-(2,2-Dimethyl-6-methylsulfanyl-2,3-dihydro-thiopyran-4-ylidene)-morpholin-4-ium; iodide 
• 62-53-3 aniline 
• 84260-97-9 (2,2-Dimethyl-6-methylsulfanyl-2,3-dihydro-thiopyran-4-ylidene)-diethyl-ammonium; iodide 
• 84260-99-1 1-(2,3-dihydro-2,2-dimethyl-6-methylsulfanyl-4Hthiopyran-4-ylidene)pyrrolidin-1-ium iodide 

Downstream Products

• 87992-49-2 4-anilino-6,6-dimethyl-1-phenyl-5,6-dihydropyridine-2(1H)-thione 

Relevant academic research and scientific papers

Chemistry of 2,4-Diaminothiopyranylium Iodides Syntheses of α,β,γ,δ-Unsaturated Thiocarboxamides

Aminolyses of 4-dialkylamino- and 4-alkylamino-2-methylthiothiopyranyliden iodids 2 resp. under various reaction conditions leads to assymmetrically or symmetrically substituted 2,4-bisamino- or 2,4-bisdialkylamino- and 2-alkylamino-4-dialkylamino- or 2-dialkylamino-4-alkylamino- or 2-amino-4-dialkylaminodihydrothiopyranylium iodides 3, 4, 5, 6 resp.On treatment with alkali 4-alkylamino- and 4-dialkylamino-2-alkylaminothiopyranylium iodides 3, 4 are hydrolysed to the 2-alkylimino-2H-thiopyranes 7. 4-Alkylamino-2-dialkylaminothiopyranylium iodides 5 react with alkali to give three products: the two stereoisomeres 2-dialkylamino-4-alkylimino-4H-thiopyranes 9 A,B and the N,N-substituted α,β,γ,δ-unsaturated thiocarboxamide 10.The hydrolysis of 2,4-bisdialkylaminothiopyranylium iodide 6a leads to the 2-dialkylamino-4H-thiopyran-4-one 11a, the 4-dialkylamino-2H-thiopyrane-2-one 12 and the N,N-substituted unsaturated thiocarboxamide 10d. α,β,γ,δ-unsaturated thiocarboxamides 10 a-c are formed by the reaction of 2-amino-4-dialkylaminothiopyranylium iodides 3 a-c with diluted alkali.By heating with acids 10 a-c are cyclisized to the 2-aminothiopyranylium derivates 3. - Keywords: Alkylaminothiopyranylium iodides; 2-Alkylimino-2H-thiopyranes; 4-Alkylimino-4H-thiopyranes; 2,4-Diaminothiopyranylium iodides; Thiocarboxamides, α,β,γ,δ-unsaturated

Syntheses of 1-Substituted 4-Amino-2(1H)-pyridinethione by Dimroth-Reaction of 2,4-Diaminothiopyranylium Halogenides

4-Amino-2-alkylimino-2H-thiopyranes (5) and 4-amino-2-alkylaminothiopyranylium halogenides (4) resp. on heating in refluxing D M F A are rearranged in the presence of Na-ethylate to 1-alkyl-4-aminodihydro-2(1H)-pyridinethiones (2).Also 2-methylthiothiopyranylidenammonium iodides (6) and 2-methylthio-4H-thiopyrane-4-one (7) can be transformed into 1-substituted 2(1H)-pyridinethiones (2) by heating in prim. amines.On treatment with alkali, 4-dimethylaminothiopyranylium iodide (4a) is transformed into its base 5a and hydrolyzed to 8. 5a and 8 are rearranged to the pyridinethiones 2a and the tautomers 9 A, B.The structure of the rearranged pyridinethiones 2 was proved by the 1-phenylderivate 2a.Thus 4-methyl-3-penten-2-on reacts with phenylthiourea via the phenylimino-1,3-thiazine (14) to give 3-phenyl-2(1H)pyridinethione (15). 15 is transformed by the methylpyrimidine-pyridine-rearrangement to the 1-phenylpyridinethione 2a.The mechanism of the Dimroth-reaction of 2-alkylimino-2H-thiopyranes (5) and the stereochemistry of the 1-benzyl-6-phenyl-2(1H)-pyridinethiones 2 are discussed. - Keywords: Conformational analysis of benzyl phenyl 2(1H) pyridinethiones; Dimroth-reaction; Keto-enol-tautomerism of 1-substituted 4-hydroxy-2(1H)-pyridinethiones; 2-Methylthiothiopyranylidenammonium iodides and 2-methylthio-4H-thiopyrane-4-one, reaction with primary amines