86798-44-9Relevant academic research and scientific papers
Process for producing aromatic isothiocyanate derivatives
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, (2008/06/13)
There is disclosed a process for producing an aromatic isothiocyanate derivative of the general formula [ I ]: wherein X is chlorine or -O-; when X is chlorine, Y is -O- or -S-, and Z is hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, alkoxycarbonyl, cycloalkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl or cycloalkoxycarbonylalkyl, or when X is -O-, X and Z are taken together to form -O-CH2-CO-, and Y is -NR- wherein R is hydrogen, alkyl, cycloalkyl, alkenyl or alkynyl, which process including reacting an aromatic amine derivative of the general formula [II]: wherein X, Y and Z are each as defined above, with carbon disulfide in the presence of a base in a nitrogen-containing polar solvent, and then with a chlorinated oxidizing agent.
