868-24-6Relevant academic research and scientific papers
Synthesis of 2′,3′-dideoxy-2′-fluoro-4′- thionucleosides from a fluoroxanthate
Jean-Baptiste, La?titia,Lefebvre, Pierre,Pfund, Emmanuel,Lequeux, Thierry
, p. 817 - 820 (2008)
The synthesis of a thiobutyrolactone as precursor of modified nucleosides is reported from a fluoroxanthate and a protected allylic alcohol. This approach opens a new and straightforward route for the synthesis of 2′,3′- dideoxy-2′-fluoro-4′-thiothymidine derivatives in few steps, including the formation of a fluorothiolactone and a Vorbrüggen thymine base alkylation reaction. Georg Thieme Verlag Stuttgart.
