86804-50-4Relevant academic research and scientific papers
Synthesis and antiviral activity of some novel substituted phenothiazines
Pandey,Saxena,Joshi,Bajpai
, p. 1015 - 1017 (2007/10/03)
Hydroquinone on reaction with amido alcohols 1 in the presence of conc. H2SO4 gives 2-arylamido/imidoalkyl-1,4-dihydroxy-benzenes 2 which undergo cyclization with aromatic primary amine and sulphur in the presence of iodine to yield 2-arylamido/imidoalkyl-10H-phenothiazin-3-ols 3. Compounds 3 are further substituted to 2-arylamido/imidoalkyl-10-[(4- methoxyphenyl/phenyl) phenylamino-methyl]-10H-phenothiazin-3-ols 4. Compounds 4 have been screened for their antiviral activity against Japanese encephalitis virus (JEV) and Herpes simplex virus type-I (HSV-I).
