868054-77-7Relevant academic research and scientific papers
Small molecule inhibitors of bacterial quorum sensing and biofilm formation
Geske, Grant D.,Wezeman, Rachel J.,Siegel, Adam P.,Blackwell, Helen E.
, p. 12762 - 12763 (2005)
Bacteria monitor their local population densities using small molecules (or autoinducers) in a process known as quorum sensing. Here, we report a new and efficient synthetic route to naturally occurring bacterial autoinducers [N-acyl L-homoserine lactones (AHLs)] that is readily amenable to the synthesis of analogues. This route has been applied in the first synthesis of a library of non-native AHLs. Evaluation of these compounds in bacterial reporter gene and biofilm assays has revealed a potent set of quorum sensing antagonists. These ligands will serve as valuable new tools to explore the role of quorum sensing in bacterial pathogenesis. Copyright
The second generation synthesis of (±)-berkeleyamide D
Mizutani, Shoma,Komori, Kenta,Kai, Chiharu,Kuramochi, Kouji,Tsubaki, Kazunori
, p. 6640 - 6645 (2016/09/28)
Previously, our group reported the first synthesis of (±)-berkeleyamide D, optical resolution of both enantiomers, and determination of their absolute configuration. The synthesis provided (±)-berkeleyamide D in a total of eight steps from commercially av
