868063-60-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-methoxyphenyl)-1,4-diazepane is used as a research compound for studying the role of serotonin receptors in various physiological and pathological processes. Its interaction with serotonin receptors makes it a valuable tool in understanding the underlying mechanisms of central nervous system disorders.
1-(4-methoxyphenyl)-1,4-diazepane is also used as a potential therapeutic agent for the development of novel treatments for psychiatric and neurological conditions. Its potent ligand properties and the presence of a methoxyphenyl group contribute to its potential efficacy in addressing these conditions.

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 868063-59-6 4-(4-methoxyphenyl)-1,4-diazepane-1-carboxylic acid tert-butyl ester 
• 112275-50-0 tert-butyl 1,4-diazepine-1-carboxylate 

Downstream Products

• 1414740-62-7 C₂₁H₂₇N₃O₃ 
• 1243544-16-2 5-[4-(4-methoxyphenyl)-1,4-diazepan-1-yl]-2,2,4,6,7-pentamethyl-1-benzofuran-3(2H)-one 
• 868063-58-5 3-amino-4-[4-(4-methoxyphenyl)-1,4-diazepan-1-yl]thieno[2,3-b]pyridine-2-carboxamide 
• 868063-61-0 (Z)-2-cyano-3-[4-(4-methoxyphenyl)-1,4-diazepan-1-yl]but-2-enethioamide 
• 1208252-39-4 N-(5-tert-butyl-2-methylphenyl)-2-[4-(4-methoxyphenyl)-1,4-diazepan-1-yl]-7-methyl-7H-purin-6-amine 

Relevant academic research and scientific papers

Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents

A cell-based assay was performed for the discovery of novel bone anabolic agents. Alkaline phosphatase (ALPase) activity of ST2 cells was utilized as an indicator of osteoblastic differentiation, and thienopyridine derivative 1 was identified as a hit compound. 3-Aminothieno[2,3-b]pyridine-2-carboxamide was confirmed to be a necessary core structure for the enhancement of ALPase activity, and then optimization of the C4-substituent on the thienopyridine ring was carried out. Introduction of cyclic amino groups to the C4-position of the thienopyridine ring improved the activity. Especially, N-phenyl-homopiperazine derivatives were found to be strong enhancers of ALPase among this new series. Furthermore, 3-amino-4-(4-phenyl-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2- carboxamide (15k) was orally administered to ovariectomized (OVX) rats over 6 weeks for evaluating the effects on areal bone mineral density (aBMD), and statistically significant improvements in aBMD were observed from the dosage of 10 mg/kg/day.

Discovery of small molecules that inhibit melanogenesis via regulation of tyrosinase expression

5,6,7,8-Tetrahydro-4H-cyclohepta[d]isoxazole derivatives were synthesized and evaluated as a novel class of inhibitors for α-melanocyte-stimulating hormone (α-MSH) induced melanogenesis in a mouse melanoma B16F10 cell line. Compound 8e (IC50 = 0.67 μM), 8h (IC50 = 1.01 μM) and 9b (IC50 = 0.99 μM) exhibited a potent inhibitory activity approximately 85- to 126-fold greater than kojic acid, a well-known potent inhibitor. A biochemical study indicates that the activity of this series should be displayed via down-regulation of the expression of tyrosinase.

THIENOPYRIDINE DERIVATIVES

The present invention provides a compound promoting osteogenesis. The present invention provides a compound having the following general formula (I) wherein R 1 is H or alkyl, R 2 is R a S-, R a O-, R a NH-, R a (R b )N- or cyclic amino, and R a and R b are alkyl which may be substituted, cycloalkyl which may be substituted, or the like, or a pharmacologically acceptable salt thereof.