868077-44-5

Usage

Uses

Used in Pharmaceutical Industry:
1-(5-Nitro-2-pyridinyl)piperidine-4-carboxylic acid serves as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential applications in treating a range of medical conditions. The presence of the nitro group and the piperidine ring are particularly beneficial for creating molecules with enhanced biological activity and selectivity.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(5-Nitro-2-pyridinyl)piperidine-4-carboxylic acid is utilized in the production of compounds with pesticidal properties. Its chemical structure contributes to the creation of effective agrochemicals that can protect crops from pests and diseases, thereby supporting agricultural productivity.
Used in Organic Synthesis:
1-(5-Nitro-2-pyridinyl)piperidine-4-carboxylic acid is a versatile building block in organic synthesis, allowing for the construction of a variety of complex organic molecules. Its reactivity and functional groups make it an essential component in the synthesis of advanced materials and specialty chemicals.
Safety Considerations:
Due to the presence of a nitro group, 1-(5-Nitro-2-pyridinyl)piperidine-4-carboxylic acid must be handled and stored with caution. Nitro compounds can be potentially explosive under certain conditions, and therefore, appropriate safety measures should be taken to mitigate risks during its use in research and industrial applications.

InChI:InChI=1/C11H13N3O4/c15-11(16)8-3-5-13(6-4-8)10-2-1-9(7-12-10)14(17)18/h1-2,7-8H,3-6H2,(H,15,16)

Upstream product

• 498-94-2 isonipecotic acid 
• 4548-45-2 2-chloro-5-nitropyridine 

Downstream Products

• 868077-45-6 (4-[3-piperidinopropoxy]phenyl)-(1-[5-nitropyridin-2-yl]piperidin-4-yl)methanone 

Relevant academic research and scientific papers

Search for histamine H3 receptor antagonists with combined inhibitory potency at Nτ-methyltransferase: Ether derivatives

With the recent development of new hybrid compounds having histamine H 3 receptor antagonist with combined histamine Nτ- methyltransferase (HMT) inhibitory potency an innovative approach was described in the research of novel lead compounds modulating histaminergic neurotransmission. Several compounds containing an ether moiety derived from the recently published 4-(3-piperidinopropoxy)phenylaminoquinoline derivatives (like FUB 836), were synthesized in this study and tested for their affinity at cloned human histamine H3 (hH3) receptors and on the inhibition of rat HMT. Besides different heterocycles, e.g. nitro- or amino-substituted pyridines, quinolines, benzothiazole or pyrroline, three classes of compounds were produced: heteroaromatic 3-piperidinopropyl ethers, keto- or imino-substituted 4-(3-piperidinopropyl)phenyl ethers and 4-(3-piperidinopropyl)phenyl ethers with substituted (alkyl)aminopyridines. Whereas the (3-piperidinopropoxy)heterocycles showed only moderate activities on both test models, the 4-(3-piperidinopropoxy)phenyl derivatives were identified as potent histamine H3 receptor ligands and/or HMT inhibitors. Ki values up to 0.42 nM were found for the affinity to the hH 3 receptor. HMT inhibitory potency was identified with IC 50 values about 0.3 μM for the most potent compounds in this series. Comparison of the pyridine-containing derivatives to recently published quinoline analogues showed a decrease in potencies for the pyridines. The dual activity, H3 receptor affinity and HMT inhibition, was moderate to good. For all compounds affinities at hH3 receptors were higher than their inhibitory HMT potencies. The described new histamine H3 receptor antagonists with an ether moiety represent a further promising step in our investigations for a dual activity.