868082-98-8

Upstream product

• 76899-07-5 (3R,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one 
• 52267-51-3 benzyl diazoacetate 
• 86978-81-6 (3R,4R)-4-acetoxy-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-1-trimethylsilyl-2-azetidinone 
• 868082-96-6 [(S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-(2Z)-ylidene]-acetic acid benzyl ester 

Downstream Products

• 868083-08-3 4-Hydroxy-3,5-dimethoxy-benzoic acid (R)-1-{(S)-2-[1-benzyloxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-3-yl}-ethyl ester 
• 868083-02-7 3,4,5-Trimethoxy-benzoic acid (R)-1-{(S)-2-[1-benzyloxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-3-yl}-ethyl ester 

Relevant academic research and scientific papers

4-Alkyliden-azetidinones modified with plant derived polyphenols: Antibacterial and antioxidant properties

Antimicrobial resistance is one of the major and growing concerns in hospital- and community acquired infections, and new antimicrobial agents are therefore urgently required. It was reported that oxidative stress could contribute to the selection of resistant bacterial strains, since reactive oxygen species (ROS) revealed to be an essential driving force. In the present work 4-alkylidene-azetidinones, a new class of antibacterial agents, were functionalized with phytochemical polyphenolic acids such as protocatechuic, piperonyl, caffeic, ferulic, or sinapic acids and investigated as dual target antibacterial-antioxidant compounds. The best candidates showed good activities against multidrug resistant clinical isolates of MRSA (MICs 2–8 μg/mL). Among the new compounds, two revealed the best antioxidant capacity with TEAC-DPPH and TEAC-ABTS being significantly more active than Trolox.

Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: New products with promising antibiotic activity against resistant bacteria

The design, synthesis, and antibacterial activity of 4-alkyliden-azetidin- 2-ones as new antimicrobial agents against multidrug-resistant pathogens is reported. 4-Alkyliden-azetidin-2-ones were easily obtained using an original protocol starting from 4-ac

4-Alkyliden-β-lactams conjugated to polyphenols: Synthesis and inhibitory activity

A series of compounds combining the β-lactam and polyphenol scaffold have been prepared and evaluated for inhibition of human leukocyte elastase and matrix metallo-proteases MMP-2 and MMP-9. The design of these compounds has been based on the 'overlapping