868083-12-9Relevant academic research and scientific papers
4-Alkyliden-β-lactams conjugated to polyphenols: Synthesis and inhibitory activity
Cainelli, Gianfranco,Galletti, Paola,Garbisa, Spiridione,Giacomini, Daria,Sartor, Luigi,Quintavalla, Arianna
, p. 6120 - 6132 (2005)
A series of compounds combining the β-lactam and polyphenol scaffold have been prepared and evaluated for inhibition of human leukocyte elastase and matrix metallo-proteases MMP-2 and MMP-9. The design of these compounds has been based on the 'overlapping
