86816-18-4Relevant academic research and scientific papers
Direct Coupling of Functionalized Organolithium Compounds with Aryl and Vinyl Halides
Barluenga, Jose,Montserrat, Javier M.,Florez, Josefa
, p. 5976 - 5980 (1993)
The reaction between β- and γ-nitrogen-functionalized and γ- and ε-oxygen-functionalized organolithium compounds 3, 4, 30-32 and different aromatic, heteroaromatic, and vinylic halides affords directly the corresponding substitution products: functionalized benzamides 5-26 and alcohols 33-37.Symmetrical and mixed products of double coupling 38-40 were also prepared from 1,4-diiodobenzene.The formation of alkyl halides as intermediates has been verified.Aryl or vinyl halides giving rise to unstable aryl or vinyllithium reagents were unsuccessful in the coupling reaction.
