868224-68-4Relevant academic research and scientific papers
Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds
Roth, Joshua,Madoux, Franck,Hodder, Peter,Roush, William R.
, p. 2628 - 2632 (2008)
Three synthetic routes were developed for structure-activity relationship (SAR) studies of HTS-derived isoquinolinone inhibitor probes for the orphan nuclear receptor steroidogenic factor-1 (NR5A1). Among the new analogs reported herein, 31 and 32 have im
