868227-84-3

Upstream product

• 923012-21-9 (+)-scabronine G methyl ester 
• 868227-83-2 (3aS,5aR,9aR)-1-Isopropyl-5a-methyl-6-oxo-7-[1-propylsulfanyl-meth-(E)-ylidene]-2,3,4,5,5a,6,7,8,9,9a-decahydro-cyclopenta[a]naphthalene-3a-carboxylic acid methyl ester 
• 287401-07-4 CH₂CH₂COCHC₂CH₃CO(CH₂)3CH₂CH₂OCO₂CH₃H 
• 117556-90-8 (8aR)-3,4,8,8a-tetrahydro-8a-methyl-1,6(2H,7H)-naphthalenedione 1-ethylene ketal 
• 868227-81-0 C₁₈H₂₂F₃NO₅S 
• 868227-72-9 C₁₆H₂₁F₃O₇S 
• 868227-87-6 C₂₀H₃₀O₄ 
• 868227-88-7 C₂₁H₃₂O₄ 
• 868227-82-1 C₂₀H₂₉NO₂ 
• 868227-86-5 C₂₀H₃₀O₃ 
• 868227-74-1 (3aS,5aR,9aR)-1-Isopropyl-5a-methyl-6-oxo-2,3,4,5,5a,6,7,8,9,9a-decahydro-cyclopenta[a]naphthalene-3a-carboxylic acid methyl ester 
• 868227-73-0 C₁₆H₂₂O₃ 
• 868227-85-4 C₁₆H₂₅NO₄ 
• 868227-80-9 C₁₆H₂₂O₃ 

Relevant academic research and scientific papers

Total synthesis of (-)-scabronine G, an inducer of neurotrophic factor production

The total synthesis of (-)-scabronine G has been achieved in a concise manner from the (-)-Wieland-Miescher ketone. Scabronine G and its more potent methyl ester (also prepared) display activity as nonpeptidyl inducers of nerve growth factor production. C

SYNTHESIS OF SCABRONINES AND ANALOGUES THEREOF

A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. T