868241-48-9 Usage
Uses
Used in Pharmaceutical Industry:
2,2-Difluoropropylamine hydrochloride is used as a key intermediate in the synthesis of new drugs for various therapeutic applications. The presence of fluorine atoms in its structure endows the resulting compounds with unique properties, such as increased lipophilicity, metabolic stability, and bioavailability, which are crucial for drug development.
Used in Chemical Research:
In the field of chemical research, 2,2-Difluoropropylamine hydrochloride serves as a versatile building block for the creation of fluorinated organic molecules. These molecules have a wide range of applications, including agrochemicals, materials science, and specialty chemicals. The incorporation of fluorine atoms can significantly alter the reactivity, selectivity, and physical properties of the synthesized compounds, making them suitable for various applications.
Used in the Synthesis of Fluorinated Compounds:
2,2-Difluoropropylamine hydrochloride is used as a starting material for the synthesis of fluorinated compounds, which exhibit unique properties due to the high electronegativity and small size of fluorine atoms. These fluorinated compounds find applications in various industries, such as pharmaceuticals, agrochemicals, and materials science, where they can improve the performance, stability, and selectivity of the final products.
Check Digit Verification of cas no
The CAS Registry Mumber 868241-48-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,8,2,4 and 1 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 868241-48:
(8*8)+(7*6)+(6*8)+(5*2)+(4*4)+(3*1)+(2*4)+(1*8)=199
199 % 10 = 9
So 868241-48-9 is a valid CAS Registry Number.
InChI:InChI=1/C3H7F2N.ClH/c1-3(4,5)2-6;/h2,6H2,1H3;1H
868241-48-9Relevant academic research and scientific papers
Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)- 6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8-(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity
Dow, Robert L.,Carpino, Philip A.,Hadcock, John R.,Black, Shawn C.,Iredale, Philip A.,DaSilva-Jardine, Paul,Schneider, Steven R.,Paight, Ernest S.,Griffith, David A.,Scott, Dennis O.,O'Connor, Rebecca E.,Nduaka, Chudy I.
supporting information; experimental part, p. 2652 - 2655 (2010/03/03)
We report the design, synthesis, and structure-activity relationships of novel bicyclic lactam-based cannabinoid type 1 (CB1) receptor antagonists. Members of these series are potent, selective antagonists in in vitro/in vivo efficacy models of CB1 antagonism and exhibit robust oral activity in rodent models of food intake. These efforts led to the identification of 19d, which has been advanced to human clinical trials for weight management.
