868258-16-6Relevant academic research and scientific papers
Total synthesis of lithospermic acid using Fe-catalyzed Cross-Dehydrogenative-Coupling reaction and Pd-catalyzed ester-directed C–H olefination
Zheng, Yong,Song, Weibin,Zhu, Yefu,Wei, Bole,Xuan, Lijiang
, p. 5950 - 5954 (2018/09/06)
The total synthesis of lithospermic acid has been accomplished employing two C–H activation reactions as key steps. Fe-catalyzed Cross-Dehydrogenative-Coupling reaction was used for the rapid construction of benzofuran framework. Pd-catalyzed ester-direct
Highly convergent total synthesis of (+)-lithospermic acid via a late-stage intermolecular C-H olefination
Wang, Dong-Hui,Yu, Jin-Quan
, p. 5767 - 5769 (2011/06/22)
The total synthesis of (+)-lithospermic acid is reported, which exploits two successive C-H activation reactions as key steps. Rh-catalyzed carbene C-H insertion reaction utilizing Davies's catalyst was used to forge dihydrobenzofuran core, and a late-sta
Total synthesis of (+)-lithospermic acid by asymmetric intramolecular alkylation via catalytic C-H bond activation
O'Malley, Steven J.,Tan, Kian L.,Watzke, Anja,Bergman, Robert G.,Ellman, Jonathan A.
, p. 13496 - 13497 (2007/10/03)
The total synthesis of (+)-lithospermic acid is described. The efficient synthesis features an asymmetric alkylation via C-H bond activation to assemble the dihydrobenzofuran core of the natural product. This was accomplished via a chiral imine-directed C
