868258-56-4Relevant academic research and scientific papers
Structure-activity relationships for antibacterial to antifungal conversion of kanamycin to amphiphilic analogues
Fosso, Marina,AlFindee, Madher N.,Zhang, Qian,Nziko, Vincent De Paul Nzuwah,Kawasaki, Yukie,Shrestha, Sanjib K.,Bearss, Jeremiah,Gregory, Rylee,Takemoto, Jon Y.,Chang, Cheng-Wei Tom
, p. 4398 - 4411 (2015/05/13)
Novel fungicides are urgently needed. It was recently reported that the attachment of an octyl group at the O-4″ position of kanamycin B converts this antibacterial aminoglycoside into a novel antifungal agent. To elucidate the structure-activity relation
Glycodiversification for the optimization of the kanamycin class aminoglycosides
Wang, Jinhua,Li, Jie,Chen, Hsiao-Nung,Chang, Huiwen,Tanifum, Christabel Tomla,Liu, Hsiu-Hsiang,Czyryca, Przemyslaw G.,Chang, Cheng-Wei Tom
, p. 6271 - 6285 (2007/10/03)
In an effort to optimize the antibacterial activity of kanamycin class aminoglycoside antibiotics, we have accomplished the synthesis and antibacterial assay of new kanamycin B analogues. A rationale-based glycodiversification strategy was employed. The a
