868266-90-4Relevant articles and documents
Azeotropic reflux chromatography: An efficient solution to a difficult separation in the scale-up synthesis of spongistatin 1
O'Brien, Matthew,Dieguez-Vazquez, Alejandro,Hsu, Day-Shin,Kraus, Helmut,Sumino, Yukihito,Ley, Steven V.
scheme or table, p. 1159 - 1164 (2008/10/09)
Azeotropic reflux chromatography (in which the eluent is continuously recycled by means of refluxing) was used to separate a mixture of spiroketal intermediates in the scale-up synthesis of spongistatin 1, leading to an improved separation and an approxim
Total synthesis of Spongistatin 1: A synthetic strategy exploiting its latent pseudo-symmetry
Ball, Matthew,Gaunt, Matthew J.,Hook, David F.,Jessiman, Alan S.,Kawahara, Shigeru,Orsini, Paolo,Scolaro, Alessandra,Talbot, Adam C.,Tanner, Huw R.,Yamanoi, Shigeo,Ley, Steven V.
, p. 5433 - 5438 (2007/10/03)
(Chemical Equation Presented) The challenging structure and potent growth inhibition properties against a variety of human cancer cell lines make Spongistatin 1 (1) an exciting target for total synthesis. Enantioselective total synthesis has been achieved