868271-10-7Relevant academic research and scientific papers
Biosynthesis of phoslactomycins: Cyclohexanecarboxylic acid as the starter unit
Sekiyama, Yasuyo,Palaniappan, Nadaraj,Reynolds, Kevin A.,Osada, Hiroyuki
, p. 7465 - 7471 (2003)
Phoslactomycins (PLMs) A-F, produced by actinomycetes are polyketide-type antibiotics derived from a hydroxycyclohexanecarboxylic acid or a cyclohexanecarboxylic acid starter unit. Feeding experiments with [2- 13C]shikimic acid indicated that the C-18 carbon of PLMs comes from C-5 of shikimate. Further feeding studies of cis and trans-3-hydroxy[7- 13C]cyclohexanecarboxylic acid, [7-13C]- and [ 2H11]cyclohexanecarboxylic acid have suggested that the starter unit in the PLM biosynthesis is not cis-3-hydroxycyclohexanecarboxylate but cyclohexanecarboxylate and that PLM-B is produced initially, and subsequently converted to other analogs by hydroxylation and acylation.
