86832-06-6 Usage
Uses
Used in Pharmaceutical Industry:
1-(4-Nitrobenzyloxycarbonyl)benzotriazole is used as a protecting group agent for the synthesis of peptides. It is employed to protect amino groups during the synthesis process, preventing unwanted side reactions and ensuring the correct formation of peptide bonds. This protection allows for the controlled and efficient synthesis of complex peptide structures, which are crucial for the development of new drugs and therapeutic agents.
Used in Research and Development:
1-(4-Nitrobenzyloxycarbonyl)benzotriazole is used as a research tool in the field of synthetic chemistry. It is utilized in the development of new synthetic methods and techniques for the synthesis of peptides and other complex organic molecules. Its stability, compatibility with various reagents and solvents, and easy removal under mild acidic conditions make it an ideal candidate for exploring new synthetic pathways and improving existing ones.
Used in Chemical Synthesis:
1-(4-Nitrobenzyloxycarbonyl)benzotriazole is used as a reagent in the synthesis of various organic compounds. Its ability to protect amino groups during chemical reactions allows for the selective formation of desired products, reducing the occurrence of side reactions and improving the overall yield of the synthesis. This makes it a valuable tool for the preparation of complex organic molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 86832-06-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,8,3 and 2 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 86832-06:
(7*8)+(6*6)+(5*8)+(4*3)+(3*2)+(2*0)+(1*6)=156
156 % 10 = 6
So 86832-06-6 is a valid CAS Registry Number.
86832-06-6Relevant academic research and scientific papers
Cinnamoyl inhibitors of tissue transglutaminase
Pardin, Christophe,Pelletier, Joelle N.,Lubell, William D.,Keillor, Jeffrey W.
, p. 5766 - 5775 (2008/12/22)
(Figure Presented) Transglutaminases (TGases) catalyze the intermolecular cross-linking of certain proteins and tissue TGases (TG2) are involved in diverse biological processes. Unregulated, high TGase activities have been implicated in several physiological disorders, but few reversible inhibitors of TG2 have been reported. Herein, we report the synthesis of a series of novel trans-cinammoyl derivatives, discovered to be potent inhibitors of guinea pig liver transglutaminase. The most effective inhibitors evaluated can be sorted into two subclasses: substituted cinnamoyl benzotriazolyl amides and the 3-(substituted cinnamoyl)pyridines, referred to more commonly as azachalcones. Kinetic evaluation of both of these subclasses revealed that they display reversible inhibition and are competitive with acyl donor TGase substrates at IC50 values as low as 18 μM. An analysis of structure - activity relationships within these series of inhibitors permitted the identification of potentially important binding interactions. Further testing of some of the most potent inhibitors demonstrated their selectivity for TG2 and their potential for further development.
CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE
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Page/Page column 71, (2009/01/20)
A compound of Formula, (I) or Formula: (II)
Synthetic substrates for enzyme analysis
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, (2008/06/13)
Synthetic substrates are provided which may be represented as A-D. The A moiety thereof includes an amino acid, polypeptide, or derivative thereof. The D moiety thereof includes 7-amino coumarin derivatives having an electron withdrawing substituent group
