86832-77-1

Basic information

• Product Name: 3-chloro-5-[(2E,6E)-7-(5,5-dimethyl-4-oxotetrahydrofuran-2-yl)-3-methylocta-2,6-dien-1-yl]-4,6-dihydroxy-2-methylbenzaldehyde
• Synonyms: Benzaldehyde, 3-chloro-4,6-dihydroxy-2-methyl-5-(3-methyl-7-(tetrahydro-5,5-dimethyl-4-oxo-2-furanyl)-2,6-octadienyl)-, (E,E)-
• CAS NO: 86832-77-1
• Molecular Formula: C₂₃H₂₉ClO₅
• Molecular Weight: 420.9264
• Mol File: 86832-77-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 581.2°C at 760 mmHg
• Flash Point: 305.3°C
• Density: 1.207g/cm³
• Vapor Pressure: 4.18E-14mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: 3-chloro-5-[(2E,6E)-7-(5,5-dimethyl-4-oxotetrahydrofuran-2-yl)-3-methylocta-2,6-dien-1-yl]-4,6-dihydroxy-2-methylbenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-5-[(2E,6E)-7-(5,5-dimethyl-4-oxotetrahydrofuran-2-yl)-3-methylocta-2,6-dien-1-yl]-4,6-dihydroxy-2-methylbenzaldehyde(86832-77-1)
• EPA Substance Registry System: 3-chloro-5-[(2E,6E)-7-(5,5-dimethyl-4-oxotetrahydrofuran-2-yl)-3-methylocta-2,6-dien-1-yl]-4,6-dihydroxy-2-methylbenzaldehyde(86832-77-1)

Safety Data

• Hazardous Substances Data: 86832-77-1(Hazardous Substances Data)

Upstream product

• 115-22-0 3-Hydroxy-3-methyl-2-butanone 
• 38290-52-7 (2E,6E)-(RS)-2,6-dimethyl-8-(tetrahydro-pyran-2-yloxy)-octa-2,6-dienal 
• 83324-59-8 3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde 
• 1181727-06-9 5-[(1E,5E)-7-acetoxy-1,5-dimethyl-1,5-heptadienyl]-2,2-dimethyl-3-oxolen-3-yl pivalate 
• 1181727-04-7 (2E,6E)-11-hydroxy-3,7,11-trimethyl-8-pivaloxy-2,6-dodecadien-9-ynyl acetate 
• 1181727-03-6 (2E,6E)-8,11-dihydroxy-3,7,11-trimethyl-2,6-dodecadien-9-ynyl acetate 
• 1181727-08-1 5-[(1E,5E)-7-bromo-1,5-dimethyl-1,5-heptadienyl]-4,5-dihydro-2,2-dimethyl-3(2H)-furanone 
• 86771-38-2 (6E,10E)-2,5-Dihydroxy-2,6,10-trimethyl-12-(tetrahydro-pyran-2-yloxy)-dodeca-6,10-dien-3-one 
• 86771-39-3 5-[(1E,5E)-1,5-Dimethyl-7-(tetrahydro-pyran-2-yloxy)-hepta-1,5-dienyl]-2,2-dimethyl-dihydro-furan-3-one 
• 105427-90-5 methyl 2,4-bis[2-(trimethylsilyl)ethoxymethoxy]-3-bromo-5-chloro-6-methylbenzoate 
• 105427-88-1 methyl 3-bromo-5-chloro-2,4-dihydroxy-6-methylbenzoate 
• 58106-55-1 2,4-dihydroxy-3-bromo-6-methyl-benzoic acid methyl ester 
• 86771-45-1 (+/-)-3-<(2'E,6'E)-7'-(3,3-dimethyl-4,4-ethylenedioxy-2-oxacyclopentyl)-3',7'-dimethyl-2',6'-heptadienyl>-1,5-dichloro-6-methyl-2,4-cyclohexanedione 
• 86771-46-2 (+/-)-4-chloro-2-<(2'E,6'E)-7'-(3,3-dimethyl-4,4-ethylenedioxy-2-oxacyclopentyl)-3',7'-dimethyl-2',6'-heptadienyl>orcinol 

Relevant articles and documents

DIHYDROOROTIC ACID DEHYDROGENASE INHIBITOR

The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I): (wherein X represents a halogen atom, R1 represents a hydrogen atom, R2 represents an alkyl group containing 1 to 7 carbon atoms, R3 represents -CHO, and R4 represents -CH2-CH=C(CH3)-R0 (wherein R0 represents an alkyl group containing 1 to 12 carbon atoms which may have a substituent on the terminal carbon and/or on a non-terminal carbon, etc.)), an optical isomer thereof or a pharmaceutically acceptable salt thereof has a high inhibitory effect on dihydroorotic acid dehydrogenase and can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anticancer agent, a therapeutic agent for graft rejection, an antiviral agent, an anti-H. pylori agent, a therapeutic agent for diabetes or the like.

A short and efficient total synthesis of (±)-ascofuranone

Ascofuranone is a potent inhibitor of trypanosome alternative oxidase. A short and efficient total synthesis of (±)-ascofuranone was accomplished in only seven steps starting with geranyl acetate. The synthetic concept and methodology described in detail

A MILD PROCEDURE FOR HYDROLYSIS OF ALKOXYMETHYL ARYL ETHERS TO GIVE HYDROXYARENES. A RATIONAL SYNTHESIS OF ASCOFURANONE

A mild procedure is reported for cleavage of alkoxymethyl aryl ethers with P2I4 to afford hydroxyarenes, and this deprotection method was successfully applied to the synthesis of an antibiotic ascofuranone through a rational approach.