86832-77-1Relevant articles and documents
DIHYDROOROTIC ACID DEHYDROGENASE INHIBITOR
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, (2015/04/15)
The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I): (wherein X represents a halogen atom, R1 represents a hydrogen atom, R2 represents an alkyl group containing 1 to 7 carbon atoms, R3 represents -CHO, and R4 represents -CH2-CH=C(CH3)-R0 (wherein R0 represents an alkyl group containing 1 to 12 carbon atoms which may have a substituent on the terminal carbon and/or on a non-terminal carbon, etc.)), an optical isomer thereof or a pharmaceutically acceptable salt thereof has a high inhibitory effect on dihydroorotic acid dehydrogenase and can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anticancer agent, a therapeutic agent for graft rejection, an antiviral agent, an anti-H. pylori agent, a therapeutic agent for diabetes or the like.
A short and efficient total synthesis of (±)-ascofuranone
Haga, Yasushi,Tonoi, Takayuki,Anbiru, Yoshihide,Takahashi, Yuki,Tamura, Sayuri,Yamamoto, Masaichi,Ifuku, Shinsuke,Morimoto, Minoru,Saimoto, Hiroyuki
, p. 622 - 623 (2011/01/07)
Ascofuranone is a potent inhibitor of trypanosome alternative oxidase. A short and efficient total synthesis of (±)-ascofuranone was accomplished in only seven steps starting with geranyl acetate. The synthetic concept and methodology described in detail
A MILD PROCEDURE FOR HYDROLYSIS OF ALKOXYMETHYL ARYL ETHERS TO GIVE HYDROXYARENES. A RATIONAL SYNTHESIS OF ASCOFURANONE
Saimoto, Hiroyuki,Kusano, Yukari,Hiyama, Tamejiro
, p. 1607 - 1610 (2007/10/02)
A mild procedure is reported for cleavage of alkoxymethyl aryl ethers with P2I4 to afford hydroxyarenes, and this deprotection method was successfully applied to the synthesis of an antibiotic ascofuranone through a rational approach.