868360-55-8Relevant academic research and scientific papers
Discovery of potent and selective bicyclic A2B adenosine receptor antagonists via bioisosteric amide replacement
Eastwood, Paul,Gonzalez, Jacob,Paredes, Sergio,Fonquerna, Silvia,Cardús, Arantxa,Alonso, Juan Antonio,Nueda, Arsenio,Domenech, Teresa,Reinoso, Raquel F.,Vidal, Bernat
, p. 1634 - 1637 (2010)
Several new potent and selective A2B adenosine receptor antagonists have been prepared in which the aryl-amide moiety of the lead series, exemplified by 1a, has been replaced by bioisosteric bicyclic moieties. Although the majority of compounds
CONDENSED PYRIDINE DERIVATIVES USEFUL AS A28 ADENOSINE RECEPTOR ANTGONISTS
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Page/Page column 38, (2008/06/13)
The present invention relates to new antagonists of the A2B adenosine receptor represented by formula (I). Those compounds are useful for treating a subject afflicted with a pathological condition or disease susceptible to amelioration by antagonism of the A2B adenosine receptor such as asthma, bronchoconstriction, allergic diseases, hypertension, atherosclerosis, reperfusion injury, myocardial ischemia, retinopathy, inflammation, gastrointestinal tract disorders, cell proliferation disorders, diabetes mellitus, and/or autoimmune diseases.
