868372-36-5

Upstream product

• 626-05-1 2,6-Dibromopyridine 
• 5980-97-2 mesitylboronic acid 
• 576-83-0 2,4,6-trimethylphenyl bromide 
• 2633-66-1 2-mesitylmagnesium bromide 

Downstream Products

• 1105699-49-7 C₁₄H₁₆N₂ 
• 1105699-39-5 C₂₈H₂₉N₃ 
• 1613741-33-5 2-(6-(2,4,6-trimethylphenyl)pyridin-2-yl)-9-(2,4,6-trimethylphenyl)[1,10]phenanthroline 
• 1613741-34-6 C₂₆H₂₁N₃ 

Relevant academic research and scientific papers

Reversible cargo shipping between orthogonal stations of a nanoscaffold upon redox input

The sterically shielded terpyridine 5 was prepared, both as a new ligand and as part of the four-station nanoscaffold 2. Mixing of terpyridine 5, the parent phenanthroline 4 and the shielded phenanthroline 3 in the presence of Zn2+ (1:1:1:1) fu

The AZARYPHOS family of ligands for ambifunctional catalysis: Syntheses and use in ruthenium-catalyzed anti-markovnikov hydration of terminal alkynes

The family of AZARYPHOS (aza-aryl-phosphane) phosphane ligands, containing a phosphine unit and sterically shielded nitrogen lone pairs in the ligand periphery, is introduced as a tool for developing ambifunctional catalysis by the metal center and nitrogen lone pairs in the ligand sphere. General synthetic strategies have been developed to synthesize over 25 examples of structurally diverse (6-aryl-2pyridyl)phosphanes (ARPYPHOS), (6alkyl-2-pyridyl)phosphanes (ALPY-PHOS), 4,6-disubsituted l,3-diazin-2ylphosphanes or l,3,5-triazin-2- ylphosphanes, quinazolinylphosphanes, quinolinylphosphanes, and others. The scalable syntheses proceed in a few steps. The incorporation of AZARYPHOS ligands (L) into complexes [RuCp(L)2(MeCN)][PF6] (Cp = cyclopentadieny1)gives catalysts for the anti-Markovnikov hydration of terminal alkynes of the highest known activities. Electronic and steric ligand effects modulate the reaction kinetics over a range of two orders of magnitude. These results highlight the importance of using structurally diverse ligand families in the process of developing cooperative ambifunctional catalysis by a metal and its ligand.

Synthesis of new dipyridinylamine and dipyridinylmethane ligands and their coordination chemistry with Mg(II) and Zn(II)

Sterically hindered, symmetrically 2,2′-substituted bispyridylamines 1a-c and methylene-bispyridine 4 were prepared in a three-step procedure from commercially available 2,6-dibromopyridine, via a Cu-mediated alkylation followed by two consecutive Buchwald-Hartwig N-arylation reactions or two Negishi cross-coupling reactions, respectively, in the presence of Pd catalysts. Deprotonation of the NH and CH2 bridge of 1a and 4, respectively, enables the formation of Zn(II) and Mg(II) complexes, whose structures have been determined by single-crystal diffraction studies and/or NMR spectroscopy. A magnesium-isopropyl complex stabilized by a bispyridyldiiminate ligand derived from 4 is shown to be an active catalyst for the isotactic polymerization of methyl methacrylate. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2008.

Highly active in situ catalysts for anti-Markovnikov hydration of terminal alkynes

(Diagram presented) The anti-Markovnikov hydration of terminal alkynes to give aldehydes is catalyzed by complexes derived in situ from air-stable [CpRu(η6-naphthalene)]PF6 (C) and 6-aryl-2- diphenylphosphinopyridines (L). Ligands L are readily available from a modular synthesis. Increasing the size of the ligand C-6 aryl group in the order R = Ph mesityl 2,4,6-triisopropylphenyl (2,4,6-triphenyl)phenyl gave hydration catalysts of highest known activity.

CYCLIC COMPOUNDS

There is provided a CRF receptor antagonist comprising a compound of the formula (I): A-W-Ar wherein, A is a group represented by the formula (A1) or (A2) (wherein, ring Aa is a 5-or 6-membered ring which may be further substituted; ring Ab is a 5-or 6-membered ring which may be further substituted; ring Ac is a 5- or 6-membered ring which may be substituted; R1 is optionally substituted alkyl, substituted amino, substituted hydroxy, etc.; X is carbonyl, -O-, -S-, etc.; Y1, Y2 and Q are independently optionally substituted carbon or nitrogen; … is a single or double bond); W is a bond, optionally substituted methylene, optionally substituted imino, -O-, -S-, etc.; Ar is optionally substituted aryl or optionally substituted heteroaryl; or a salt thereof or a prodrug thereof.