86838-01-9

Basic information

• Product Name: 1-Benzyloxy-3-isopropoxy-propan-2-ol
• CAS NO: 86838-01-9
• Molecular Weight: 224.3
• Mol File: 86838-01-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Benzyloxy-3-isopropoxy-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyloxy-3-isopropoxy-propan-2-ol(86838-01-9)
• EPA Substance Registry System: 1-Benzyloxy-3-isopropoxy-propan-2-ol(86838-01-9)

Safety Data

• Hazardous Substances Data: 86838-01-9(Hazardous Substances Data)

Upstream product

• 15028-56-5 4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolane 

Relevant articles and documents

A Selectivity Study of Activated Ketal Reduction with Borane Dimethyl Sulfide

A chemo- and regioselectivity study of the reagent combination BH3*SMe2/TMSOTf for ketal reduction has been undertaken.It has revealed that simple 1,3-dioxanes reduce cleanly at low temperature in CH2Cl2 while simple 1,3-dioxolanes may give complete ring cleavage and dimerization products.A study of reduction of 4-substituted 1,3-dioxolanes has revealed a solvent-directed regioselectivity which in THF favors the secondary protected derivative.A mechanism is postulated to account for the selectivities based on recent thinking on acetal substitution reactions.

The First Solvent-directed Regioselective Ketal Reduction of Unsymmetrical Glycols

Borane-dimethyl sulphide/TMSOTf in THF reduces ketals of unsymmetrical vicinal diols with much higher regioselectivity than with CH2Cl2 as solvent.