868406-71-7

Upstream product

• 46004-37-9 methyl 4-amino-2-chlorobenzoate 
• 2457-76-3 4-amino-2-chlorobenzoic acid 

Downstream Products

• 868406-72-8 2-(4-amino-5-bromo-2-chloro-phenyl)-propan-2-ol 
• 868406-70-6 N-[5-chloro-2-{(E)-3-[3-(4-fluoro-benzyl)-3,8-diazabicyclo[3.2.1]oct-8-yl]-3-oxopropenyl}-4-(1-hydroxy-1-methyl-ethyl)-phenyl]acetamide 
• 868406-74-0 (E)-3-[2-acetylamino-4-chloro-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-acrylic acid ethyl ester 
• 868406-73-9 (E)-3-[2-amino-4-chloro-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-acrylic acid ethyl ester 

Relevant academic research and scientific papers

FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY

The present invention provides a compound of formula (I), wherein R1, R2, R3, R4a, R4b, R5a and R5b are as defined in the description, which has an autotaxin inhibitory activity,

TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY

The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treat

COMPOUNDS AS CCRI ANTAGONISTS

A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically for treatment of diseases and conditions in which CCR-1 is implicated, e.g. inflammatory diseases.