86844-45-3Relevant academic research and scientific papers
Synthesis and Antioxidant Activity of New Norcantharidin Analogs
Pachuta-Stec, Anna,Nowak, Renata,Pietrzak, Wioleta,Pitucha, Monika
, (2019)
New norcantharidin analogs were designed and obtained as compounds with biological activity. As a starting material, exo-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid anhydride was used. Three groups of compounds: dicarboximides, triazoles and thiazolidines were obtained in multistep reactions. The 1H- and 13C-NMR spectra were used to confirm the structures of all obtained products and they were in agreement with the proposed structure of substances. All derivatives were screened for their antioxidant activity. The most promising group was dicarboximides (1–4, 6). Derivatives 2–4 displayed antioxidant activity with EC50=7.75–10.89 μg/ml, which may be comparable to strong antioxidant Trolox (EC50=6.13 μg/ml). Excellent activity with EC50=10.75 μg/ml also presented norcantharidin analog with 1,2,4-triazole system (12).
Synthesis and Anticonvulsant Activity of 7-Oxabicycloheptane Derivatives: Part 1 - N-Alkyl, N-Aryl and N-Heteroaryl Derivatives of 3,6-Epoxyhexahydrophthalimide
Joshi, Balawant S.,David, Joy,Gawad, Dilip H.
, p. 131 - 135 (2007/10/02)
A series (sixty one) of N-substituted 3,6-epoxyhexahydrophthalimides have been prepared by the condensation of the appropriately substituted alkyl, aryl and heteroarylamines with exo-cis-3,6-epoxyhexahydrophthalic anhydride (2).Some of the compounds exhib
