86845-62-7Relevant academic research and scientific papers
Synthesis and activity of novel nitropyrazines for use as hypoxic cell radiosensitizers
Hartman,Hartman,Schwering,Saari,Engelhardt,Jones,Wardman,Watts,Woodcock
, p. 1634 - 1639 (2007/10/02)
A series of eight novel nitropyrazines has been prepared by oxidation of sulfoximine intermediates. The partition coefficient, one-electron reduction potential, sensitizer enhancement ratio, and chronic and acute aerobic cytotoxicity have been measured for each. Two representatives of this series were tested in the Ames test and were not found to be mutagenic.
Synthesis and Reactions of 5,6-Dichloro-3-nitropyrazinamine
Hartman, George D.,Hartman, Richard D.
, p. 1089 - 1092 (2007/10/02)
The synthesis of 5,6-dichloro-3-nitropyrazinamine has been carried out by decarboxylative nitration of 5,6-dichloro-3-nitropyrazine-2-carboxylic acid.The nitro heterocycle was found to undergo a variety of reactions, which include nucleophilic displacement of the 6-chloro group by amines, acetylation of the free amino group with acetyl chloride, bromo-deamination with isoamylnitrite in bromoform, as well as the formation of imidazolo and triazolo condensed ring systems.
Amino derivatives of chloro nitro amino pyrazines useful as adjuncts to radiation therapy
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, (2008/06/13)
2-Substituted amino derivatives of 6-amino-3-chloro-5-nitropyrazin-2-yl are prepared by converting 3-amino-5,6-dichloropyrazinecarboxylic acid to 5,6-dichloro-3-nitropyrazinamine and treating said compound with an amine to produce the corresponding 2-substituted amino compound.
