868523-17-5

Basic information

• Product Name: (2-benzyloxycarbonylamino-ethyl)-H-phosphinic acid
• Synonyms: (2-benzyloxycarbonylamino-ethyl)-H-phosphinic acid
• CAS NO: 868523-17-5
• Molecular Weight: 243.199
• Mol File: 868523-17-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2-benzyloxycarbonylamino-ethyl)-H-phosphinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2-benzyloxycarbonylamino-ethyl)-H-phosphinic acid(868523-17-5)
• EPA Substance Registry System: (2-benzyloxycarbonylamino-ethyl)-H-phosphinic acid(868523-17-5)

Safety Data

• Hazardous Substances Data: 868523-17-5(Hazardous Substances Data)

Upstream product

• 1075799-55-1 2-aminoethyl-H-phosphinic acid hydrochloride 
• 501-53-1 benzyl chloroformate 
• 85618-16-2 2-aminoethyl-H-phosphinic acid 

Downstream Products

• 115115-40-7 (R)-1-(N-benzyloxycarbonylamino)ethylphosphinic acid 
• 868523-20-0 methyl (2S)-2-benzyloxycarbonylamino-4-[(2'-benzyloxycarbonylaminoethyl)(hydroxy)phosphinyl]butyrate 

Relevant articles and documents

Synthesis of P,N-heterocycles from ω-amino-H-phosphinates: Conformationally restricted α-amino acid analogs

(Chemical Equation Presented) P,N-Heterocycles (3-hydroxy-1,3- azaphospholane and 3-hydroxy-1,3-azaphosphorinane-3-oxide) are synthesized in moderate yield from readily available ω-amino-H-phosphinates and aldehydes or ketones via an intramolecular Kabachnik-Fields reaction. The products are conformationally restricted phosphinic analogs of α-amino acids. The multigram-scale syntheses of the H2N(CH2) nPO2H2 phosphinic precursors (n = 1, 2, 3) and some derivatives are also described.